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(b) Answer All Parts [50 marks] (i) Metallodrugs can be deactivated by peptides such as glutathione and metallothionine. Describe in detail synthetic strategies that can be used to enhance the biological stability of platinum compounds. Include relevant structures and schemes in your answer. [25 marks] (ii) Describe in detail the synthetic method used to prepare the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2]. Compare this method to that used to develop the less active isomer, trans-[Pt(NH3)2Cl2]. Describe one suitable spectroscopic and one suitable molecular (or biophysical) assay you could use to distinguish both cis- and trans- isomers. Include relevant structures and schemes in your answer. [25 marks] I

(b) Answer All Parts [50 marks] (i) Metallodrugs can be deactivated by peptides such as glutathione and metallothionine. Describe in detail synthetic strategies that can be used to enhance the biological stability of platinum compounds. Include relevant structures and schemes in your answer. [25 marks] (ii) Describe in detail the synthetic method used to prepare the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2]. Compare this method to that used to develop the less active isomer, trans-[Pt(NH3)2Cl2]. Describe one suitable spectroscopic and one suitable molecular (or biophysical) assay you could use to distinguish both cis- and trans- isomers. Include relevant structures and schemes in your answer. [25 marks] I

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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(b) Answer All Parts [50 marks] (i) Metallodrugs can be deactivated by peptides such as glutathione and metallothionine. Describe in detail synthetic strategies that can be used to enhance the biological stability of platinum compounds. Include relevant structures and schemes in your answer. [25 marks] (ii) Describe in detail the synthetic method used to prepare the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2]. Compare this method to that used to develop the less active isomer, trans-[Pt(NH3)2Cl2]. Describe one suitable spectroscopic and one suitable molecular (or biophysical) assay you could use to distinguish both cis- and trans- isomers. Include relevant structures and schemes in your answer. [25 marks] I
Transcribed Image Text:(b) Answer All Parts [50 marks] (i) Metallodrugs can be deactivated by peptides such as glutathione and metallothionine. Describe in detail synthetic strategies that can be used to enhance the biological stability of platinum compounds. Include relevant structures and schemes in your answer. [25 marks] (ii) Describe in detail the synthetic method used to prepare the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2]. Compare this method to that used to develop the less active isomer, trans-[Pt(NH3)2Cl2]. Describe one suitable spectroscopic and one suitable molecular (or biophysical) assay you could use to distinguish both cis- and trans- isomers. Include relevant structures and schemes in your answer. [25 marks] I
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