Assign R, S configurations to each indicated chirality center in the molecules below.

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter12: Chirality
Section: Chapter Questions
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**Section IX:** Assign R, S configurations to each indicated chirality center in the molecules below.

1. **Molecule with Carbon 14**: 
   - Structure: Aromatic benzene ring with hydroxyl groups (OH) and an amine group (CH₂NH₂) attached.
   - Assigned chirality center: Carbon 14.

2. **Molecule with Carbon 15**: 
   - Structure: Tetrahedral structure with a carboxylic acid group (COOH), a hydrogen, a methyl group (CH₃), and an amine group (H₂N) attached.
   - Assigned chirality center: Carbon 15.

3. **Molecule with Carbon 16**: 
   - Structure: Molecule with a hydroxyl group (OH), a hydrogen, and two carboxylic acid groups (HO₂C and CO₂H).
   - Assigned chirality center: Carbon 16.

4. **Molecule with Carbon 17 and 18**: 
   - Structure: Cyclohexanone ring with a ketone (C=O) and ethyl group (CH₃CH₂) attached.
   - Assigned chirality centers: Carbon 17 and Carbon 18.

**Answer the following:**
- The configuration of carbon 14 is _____.
- The configuration of carbon 15 is _____.
- The configuration of carbon 16 is _____.
- The configuration of carbon 17 is _____.
- The configuration of carbon 18 is _____.

**Note:** Use the Cahn-Ingold-Prelog priority rules to determine the R (rectus) or S (sinister) configuration for each chirality center designated in the molecules.
Transcribed Image Text:**Section IX:** Assign R, S configurations to each indicated chirality center in the molecules below. 1. **Molecule with Carbon 14**: - Structure: Aromatic benzene ring with hydroxyl groups (OH) and an amine group (CH₂NH₂) attached. - Assigned chirality center: Carbon 14. 2. **Molecule with Carbon 15**: - Structure: Tetrahedral structure with a carboxylic acid group (COOH), a hydrogen, a methyl group (CH₃), and an amine group (H₂N) attached. - Assigned chirality center: Carbon 15. 3. **Molecule with Carbon 16**: - Structure: Molecule with a hydroxyl group (OH), a hydrogen, and two carboxylic acid groups (HO₂C and CO₂H). - Assigned chirality center: Carbon 16. 4. **Molecule with Carbon 17 and 18**: - Structure: Cyclohexanone ring with a ketone (C=O) and ethyl group (CH₃CH₂) attached. - Assigned chirality centers: Carbon 17 and Carbon 18. **Answer the following:** - The configuration of carbon 14 is _____. - The configuration of carbon 15 is _____. - The configuration of carbon 16 is _____. - The configuration of carbon 17 is _____. - The configuration of carbon 18 is _____. **Note:** Use the Cahn-Ingold-Prelog priority rules to determine the R (rectus) or S (sinister) configuration for each chirality center designated in the molecules.
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