ased off the information given, complete the table a. What mode of inheritance pattern best fits this pedigree in your opinion?

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Based off the information given, complete the table a. What mode of inheritance pattern best fits this pedigree in your opinion?
You are a second-year medical student in an innovative medical school that allows you to get in-depth clinical experience early in your medical education. You are currently assigned to work with Dr. Aikenhed, a pediatric oncologist. She has done a biopsy on a tumor-like growth in the adrenal gland of her 17-year-old male patient, Lee F. You record the following notes while Dr. Aikenhed takes a detailed family history from the patient’s parents:

- Lee has a sister, Leah (age 10), and a brother, Luke (age 6). Both are healthy.
- Lee’s mother, Grace, was diagnosed with bilateral breast cancer last year at age 35. Lee’s father, Brian, and Lee’s paternal grandparents have no history of cancer.
- Grace is the youngest of four children. Her eldest brother, Greg (age 42), and sister, Greta (age 40), have never had any signs or symptoms of cancer. She had a brother, Geoff, who died of leukemia at age 8. He was the third child of Grace’s parents.
- Greg’s two fraternal twin daughters have no signs or symptoms of cancer.
- Grace’s father, Roger, died of a soft tissue sarcoma at age 35. Grace’s mother, Renee, is still living and in excellent health.
- Roger’s mother died of a brain tumor at age 30. Roger was her only child.
Transcribed Image Text:You are a second-year medical student in an innovative medical school that allows you to get in-depth clinical experience early in your medical education. You are currently assigned to work with Dr. Aikenhed, a pediatric oncologist. She has done a biopsy on a tumor-like growth in the adrenal gland of her 17-year-old male patient, Lee F. You record the following notes while Dr. Aikenhed takes a detailed family history from the patient’s parents: - Lee has a sister, Leah (age 10), and a brother, Luke (age 6). Both are healthy. - Lee’s mother, Grace, was diagnosed with bilateral breast cancer last year at age 35. Lee’s father, Brian, and Lee’s paternal grandparents have no history of cancer. - Grace is the youngest of four children. Her eldest brother, Greg (age 42), and sister, Greta (age 40), have never had any signs or symptoms of cancer. She had a brother, Geoff, who died of leukemia at age 8. He was the third child of Grace’s parents. - Greg’s two fraternal twin daughters have no signs or symptoms of cancer. - Grace’s father, Roger, died of a soft tissue sarcoma at age 35. Grace’s mother, Renee, is still living and in excellent health. - Roger’s mother died of a brain tumor at age 30. Roger was her only child.
**Table 1 – Determining Mode of Inheritance**

This table is used to evaluate different modes of genetic inheritance, classifying each as "Possible," "Possible but Unlikely," or "Not possible." Additionally, a brief rationale section is provided to explain the reasoning behind each classification.

1. **Mode of Inheritance:**

    - Autosomal recessive
    - Autosomal dominant
    - X-linked recessive
    - X-linked dominant
    - Y-linked
    - Mitochondrial

2. **Columns:**

    - **Possible:** Indication of whether the mode of inheritance is feasible based on given data.
    - **Possible but Unlikely:** This category is used when a mode is theoretically possible but not strongly supported by available evidence.
    - **Not possible:** Used when the mode of inheritance is ruled out based on the data.
    - **Brief Rationale:** Provides explanations for the decisions made in the previous columns.

The table aids in systematically analyzing genetic inheritance patterns, making it a valuable tool in educational and research settings.
Transcribed Image Text:**Table 1 – Determining Mode of Inheritance** This table is used to evaluate different modes of genetic inheritance, classifying each as "Possible," "Possible but Unlikely," or "Not possible." Additionally, a brief rationale section is provided to explain the reasoning behind each classification. 1. **Mode of Inheritance:** - Autosomal recessive - Autosomal dominant - X-linked recessive - X-linked dominant - Y-linked - Mitochondrial 2. **Columns:** - **Possible:** Indication of whether the mode of inheritance is feasible based on given data. - **Possible but Unlikely:** This category is used when a mode is theoretically possible but not strongly supported by available evidence. - **Not possible:** Used when the mode of inheritance is ruled out based on the data. - **Brief Rationale:** Provides explanations for the decisions made in the previous columns. The table aids in systematically analyzing genetic inheritance patterns, making it a valuable tool in educational and research settings.
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