Annabeth and Percy are concerned about having a child with Niemann - Pick disease, which causes abnormal accumulation of fat in cells. This condition, which is very rare, has affected Annabeth's niece (her brother's daughter) and Percy's aunt (his father's sister ). No one else in either family has the condition. What is the probability Annabeth and Percy's first child will have the disease? What is the probability Annabeth and Percy's first child will have the disease? 1/64 1/32 1/24 1/18 1/12 1/9 1/4 None of these above
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- Karen and Steve each have a sibling with sickle-cell disease.Neither Karen nor Steve nor any of their parents have thedisease, and none of them have been tested to see if they carrythe sickle-cell allele. Based on this incomplete information,calculate the probability that if this couple has a child, thechild will have sickle-cell disease.Three people are diagnosed with different types of cancer. One is a lifelong smoker and has lung cancer, one has active Crohn disease and colorectal cancer, and the other is a farmer with newly diagnosed melanoma. What do these individuals have in common?Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?
- Because Elsa has received a confirmed diagnosis of beta-thalassemia major, which of the following statements is true about her parents? Only her mother carried the gene that caused her blood disorder. Only her father carried the gene that caused her blood disorder. If her parents have another child naturally, there is a 100% chance that the second child will be diagnosed with beta-thalassemia major. If her parents have another child naturally, there is a 25% chance that the second child will be diagnosed with beta-thalassemia major.The pedigree for Queen Victoria of England, acarrier of hemophilia A, shows the transmission tosome of her descendants, including members ofmany royal families in Europe, such as Russia andSpain, but not Germany. Hemophilia A does notaffect anyone in the present British royal family.Can you explain why hemophilia A hasdisappeared from one family and appeared inothers?Jan and Michael are both carriers for the cystic fibrosis allele. If Jan and Michael have three children with the disease and then Jan becomes pregant with fratnernal twins, what is the probability that both twins will also have the disease?
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- Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. A young couple, Bart and Jenny, are expecting a child and are aware there might be a chance that their child could be affected by this disorder. Jenny (the wife) has ichthyosis, but Bart (her husband) is unaffected and completely normal with respect to the allele responsible for this disorder. Both Bart and Jenny were Biology majors as undergraduates. Knowing a little about the pattern of X-linked recessive inheritance, Bart and Jenny were concerned when ultrasound revealed that they would be having a son. However, genetic testing performed on the baby shortly after birth revealed that their newborn son, Mark, did not…Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?Mr. and Mrs. Smith, both 40 years of age, are healthy with no knowngenetic conditions. Their newborn child has Down syndrome (trisomy 21).Explain the events that caused this condition.