& КОН, CH3CH₂OH reflux Draw Michael Adduct Q

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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### Image Transcription for Educational Website

**Chemical Reaction Sequence**

1. **Initial Compounds:**
   - The image displays two chemical structures. The first is a six-membered cyclohexanone ring with a ketone group. The second compound is a methyl vinyl ketone, characterized by the presence of a vinyl group attached to a ketone.

2. **Reagents and Conditions:**
   - **KOH, \( \text{CH}_3\text{CH}_2\text{OH} \), reflux**
   - The reaction is carried out under reflux conditions with potassium hydroxide (KOH) in ethanol (\( \text{CH}_3\text{CH}_2\text{OH} \)) as the solvent.

3. **First Product:**
   - **Draw Michael Adduct**
   - This step involves a Michael addition reaction, where the enolate ion of the cyclohexanone adds to the α,β-unsaturated carbonyl compound (methyl vinyl ketone).

4. **Second Reaction Step:**
   - The same reagents and conditions are used again: **KOH, \( \text{CH}_3\text{CH}_2\text{OH} \), reflux**.

5. **Final Product:**
   - **Draw Robinson Product**
   - The final product forms through a series of reactions, including intramolecular aldol reaction and subsequent dehydration, leading to the formation of the Robinson annulation product.

This sequence showcases the use of alkali and alcohol in promoting organic reactions for the formation of complex cyclic structures from simpler precursors.
Transcribed Image Text:### Image Transcription for Educational Website **Chemical Reaction Sequence** 1. **Initial Compounds:** - The image displays two chemical structures. The first is a six-membered cyclohexanone ring with a ketone group. The second compound is a methyl vinyl ketone, characterized by the presence of a vinyl group attached to a ketone. 2. **Reagents and Conditions:** - **KOH, \( \text{CH}_3\text{CH}_2\text{OH} \), reflux** - The reaction is carried out under reflux conditions with potassium hydroxide (KOH) in ethanol (\( \text{CH}_3\text{CH}_2\text{OH} \)) as the solvent. 3. **First Product:** - **Draw Michael Adduct** - This step involves a Michael addition reaction, where the enolate ion of the cyclohexanone adds to the α,β-unsaturated carbonyl compound (methyl vinyl ketone). 4. **Second Reaction Step:** - The same reagents and conditions are used again: **KOH, \( \text{CH}_3\text{CH}_2\text{OH} \), reflux**. 5. **Final Product:** - **Draw Robinson Product** - The final product forms through a series of reactions, including intramolecular aldol reaction and subsequent dehydration, leading to the formation of the Robinson annulation product. This sequence showcases the use of alkali and alcohol in promoting organic reactions for the formation of complex cyclic structures from simpler precursors.
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