An article in the November 20, 2008 edition of the New England Journal of Medicine reports the results from a large, randomized study designed to assess the relationship between statin treatment and cardiovascular disease (as indicated by having at least one of several clinical endpoints). The researchers randomized 17,800 healthy (without a history of cardiovascular disease) men and women with non- elevated LDL cholesterol levels to either 20 mg of statins daily, or placebo. Subjects were followed for up to 5 years. At the end of the follow-up period the study results included the following: Of the 8900 subjects randomized to the statins group, 142 developed cardiovascular disease. Of the 8900 subjects randomized to the placebo group, 251 developed cardiovascular disease. (Reference: Ridker P, et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. New England Journal of Medicine. (2008). 359;21) What is the estimated relative risk of developing cardiovascular disease for subjects in the statins group compared to subjects on placebo? The estimated relative risk is approximately - 0.012. O The estimated relative risk is approximately 1.77 O The estimated relative risk is approximately 0.57. The estimated relative risk is approximately 0.012.
An article in the November 20, 2008 edition of the New England Journal of Medicine reports the results from a large, randomized study designed to assess the relationship between statin treatment and cardiovascular disease (as indicated by having at least one of several clinical endpoints). The researchers randomized 17,800 healthy (without a history of cardiovascular disease) men and women with non- elevated LDL cholesterol levels to either 20 mg of statins daily, or placebo. Subjects were followed for up to 5 years. At the end of the follow-up period the study results included the following: Of the 8900 subjects randomized to the statins group, 142 developed cardiovascular disease. Of the 8900 subjects randomized to the placebo group, 251 developed cardiovascular disease. (Reference: Ridker P, et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. New England Journal of Medicine. (2008). 359;21) What is the estimated relative risk of developing cardiovascular disease for subjects in the statins group compared to subjects on placebo? The estimated relative risk is approximately - 0.012. O The estimated relative risk is approximately 1.77 O The estimated relative risk is approximately 0.57. The estimated relative risk is approximately 0.012.
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Transcribed Image Text:7. An article in the November 20, 2008 edition of the New England Journal of Medicine reports the results from a large,
randomized study designed to assess the relationship between statin treatment and cardiovascular disease (as indicated
by having at least one of several clinical endpoints).
The researchers randomized 17,800 healthy (without a history of cardiovascular disease) men and women with non-
elevated LDL cholesterol levels to either 20 mg of statins daily, or placebo. Subjects were followed for up to 5 years. At the
end of the follow-up period the study results included the following:
Of the 8900 subjects randomized to the statins group, 142 developed cardiovascular disease. Of the 8900 subjects
randomized to the placebo group, 251 developed cardiovascular disease.
(Reference: Ridker P, et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein.
New England Journal of Medicine. (2008). 359;21)
What is the estimated relative risk of developing cardiovascular disease for subjects in the statins group
compared to subjects on placebo?
The estimated relative risk is approximately - 0.012.
The estimated relative risk is approximately 1.77
The estimated relative risk is approximately 0.57.
The estimated relative risk is approximately 0.012.
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