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An alpha helix of a protein has the sequence FFVGNDHMVEDVERFIREFPDA. One researcher studying this protein argues that it faces the solvent on one side and the core of the protein on the other side. A second researcher believes the entire helix is solvent exposed. Complete the helix wheel using this sequence, and then explain which researcher you think is correct and why in 25 words or less.

An alpha helix of a protein has the sequence FFVGNDHMVEDVERFIREFPDA. One researcher studying this protein argues that it faces the solvent on one side and the core of the protein on the other side. A second researcher believes the entire helix is solvent exposed. Complete the helix wheel using this sequence, and then explain which researcher you think is correct and why in 25 words or less.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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### Protein Alpha Helix Analysis #### Problem: An alpha helix of a protein has the sequence **FFVGNDHMVEDVERFIREFPDA**. One researcher studying this protein argues that it faces the solvent on one side and the core of the protein on the other side. A second researcher believes the entire helix is solvent exposed. **Task:** Complete the helix wheel using this sequence, and then explain which researcher you think is correct and why in 25 words or less. #### Diagram Explanation: The diagram provided is a helical wheel plot template, which helps visualize the spatial arrangement of amino acids in an alpha helix. - The helical wheel is divided into 18 segments, each corresponding to a position in the helix sequence. - Typically, hydrophobic (nonpolar) residues cluster together on one side of the wheel, indicating they are likely facing the core of a protein, while polar residues face the solvent. #### Steps to Complete the Helix Wheel: 1. Fill in each segment of the helical wheel with the amino acids from the sequence **FFVGNDHMVEDVERFIREFPDA** in order. 2. Analyze the pattern of hydrophobic and hydrophilic residues to determine whether one side is predominantly hydrophobic (indicating it faces the core). #### Conclusion: After completing the helix wheel and reviewing the distribution of hydrophobic and hydrophilic residues, make a determination about which researcher is correct. Provide a concise explanation (25 words or less) to justify your conclusion.
Transcribed Image Text:### Protein Alpha Helix Analysis #### Problem: An alpha helix of a protein has the sequence **FFVGNDHMVEDVERFIREFPDA**. One researcher studying this protein argues that it faces the solvent on one side and the core of the protein on the other side. A second researcher believes the entire helix is solvent exposed. **Task:** Complete the helix wheel using this sequence, and then explain which researcher you think is correct and why in 25 words or less. #### Diagram Explanation: The diagram provided is a helical wheel plot template, which helps visualize the spatial arrangement of amino acids in an alpha helix. - The helical wheel is divided into 18 segments, each corresponding to a position in the helix sequence. - Typically, hydrophobic (nonpolar) residues cluster together on one side of the wheel, indicating they are likely facing the core of a protein, while polar residues face the solvent. #### Steps to Complete the Helix Wheel: 1. Fill in each segment of the helical wheel with the amino acids from the sequence **FFVGNDHMVEDVERFIREFPDA** in order. 2. Analyze the pattern of hydrophobic and hydrophilic residues to determine whether one side is predominantly hydrophobic (indicating it faces the core). #### Conclusion: After completing the helix wheel and reviewing the distribution of hydrophobic and hydrophilic residues, make a determination about which researcher is correct. Provide a concise explanation (25 words or less) to justify your conclusion.
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