Among the newer-generation diuretics is bumetanide, prescribed under several trade names, including Bumex and Fordiuran. Following is an outline of a synthesis of this drug. NO, NO2 Cl, Cl, ONat H,N. COOH СООН 4-Chloro-3-nitrobenzoic acid Н. NO2 H,N. H,N. (3) СООН СООН Bumetanide

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Chapter1: Chemical Foundations
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Propose reagents for Step (3). Hint: It too requires more than one reagent

Among the newer-generation diuretics is bumetanide, prescribed under several trade
names, including Bumex and Fordiuran. Following is an outline of a synthesis of this
drug.
NO,
NO2
Cl,
Cl,
ONat
H,N.
COOH
СООН
4-Chloro-3-nitrobenzoic acid
Н.
NO2
H,N.
H,N.
(3)
СООН
СООН
Bumetanide
Transcribed Image Text:Among the newer-generation diuretics is bumetanide, prescribed under several trade names, including Bumex and Fordiuran. Following is an outline of a synthesis of this drug. NO, NO2 Cl, Cl, ONat H,N. COOH СООН 4-Chloro-3-nitrobenzoic acid Н. NO2 H,N. H,N. (3) СООН СООН Bumetanide
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