Alkaptonuria is a recessive autosomal genetic disorder associated with darkening of the urine. In the United States, approximately 1 out of every 250,000people has alkaptonuria.a. Assuming Hardy-Weinberg equilibrium, estimatethe frequency of the allele responsible for this trait.b. What proportion of people in the U.S. populationare carriers for this trait? In this population, whatis the ratio of carriers to individuals affected byalkaptonuria?c. If a woman without alkaptonuria had a child withthis trait with one husband then remarried, what isthe chance that a child produced by her secondmarriage would have alkaptonuria?d. Alkaptonuria is a relatively benign condition, sothere is little selective advantage to individualswith any genotype; as a result, your assumptionof Hardy-Weinberg equilibrium in part (a) is reasonable. Could you also use the assumption ofHardy-Weinberg equilibrium to estimate the allelefrequencies and carrier frequencies of more severerecessive autosomal conditions such as cysticfibrosis? Explain.
Alkaptonuria is a recessive autosomal genetic disorder associated with darkening of the urine. In the United States, approximately 1 out of every 250,000
people has alkaptonuria.
a. Assuming Hardy-Weinberg equilibrium, estimate
the frequency of the allele responsible for this trait.
b. What proportion of people in the U.S. population
are carriers for this trait? In this population, what
is the ratio of carriers to individuals affected by
alkaptonuria?
c. If a woman without alkaptonuria had a child with
this trait with one husband then remarried, what is
the chance that a child produced by her second
marriage would have alkaptonuria?
d. Alkaptonuria is a relatively benign condition, so
there is little selective advantage to individuals
with any genotype; as a result, your assumption
of Hardy-Weinberg equilibrium in part (a) is reasonable. Could you also use the assumption of
Hardy-Weinberg equilibrium to estimate the allele
frequencies and carrier frequencies of more severe
recessive autosomal conditions such as cystic
fibrosis? Explain.
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