After the RNA primers are all removed, which

Human Anatomy & Physiology (11th Edition)
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**Question:**

After the RNA primers are all removed, which enzyme is responsible for joining the fragments of DNA together into one long continuous strand?

**Explanation:**

In DNA replication, RNA primers are initially laid down to allow the DNA polymerase enzyme to begin synthesizing DNA. Once their job is completed, these RNA primers are removed, and the gaps they leave behind are filled in by DNA polymerase. However, this results in small, separate DNA fragments. The enzyme responsible for joining these fragments, known as Okazaki fragments on the lagging strand, into a continuous DNA strand is DNA ligase. DNA ligase seals the nicks between the separate fragments, ensuring the integrity and continuity of the newly synthesized DNA strand.
Transcribed Image Text:**Question:** After the RNA primers are all removed, which enzyme is responsible for joining the fragments of DNA together into one long continuous strand? **Explanation:** In DNA replication, RNA primers are initially laid down to allow the DNA polymerase enzyme to begin synthesizing DNA. Once their job is completed, these RNA primers are removed, and the gaps they leave behind are filled in by DNA polymerase. However, this results in small, separate DNA fragments. The enzyme responsible for joining these fragments, known as Okazaki fragments on the lagging strand, into a continuous DNA strand is DNA ligase. DNA ligase seals the nicks between the separate fragments, ensuring the integrity and continuity of the newly synthesized DNA strand.
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