After 3,000 BCE and the first civilizations we see the birth of epidemic diseases. What changed? What factors helped bring about epidemics?

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During the long period of time known as “Prehistory,” before the first great cities and civilization, epidemic diseases were virtually non-existent. After 3,000 BCE and the first civilizations we see the birth of epidemic diseases. What changed? What factors helped bring about epidemics? 

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