ach must have received the mutant p57 allele from their respective fathers. ach must have received the mutant p57 allele from their respective mothers. ne mother must have received the mutant p57 allele from her mother, while the father must have received the mutant p57 allele from his father. ne mother must have received the mutant p57 allele from her father, while the father must have received the mutant p57 allele from his mother. tually, there's something inconsistent here. Such phenotypes for the parents are not anticipated when an imprintable gene is involved. Scanner

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question 17
Individuals with Beckwith-Wiedemann syndrome (Bws) develop sporadic tumors due to a mutation in an imprintable gene, p57, on chrornosome 11. Normally, p57 regulates the cell
cycle. The imprint on p57 is such that only the maternal allele is expressed.
A heterozygous normal couple has two children with BWS and one normal child.
How is it possible that both parents have the mutant p57 allele to pass along, but these parents do not themselves show the cancerous phenotype?
A) Each must have received the mutant p57 allele from their respective fathers.
B) Each must have received the mutant p57 allele from their respective mothers.
C) The mother must have received the mutant p57 allele from her mother, while the father must have received the mutant p57 allele from his father.
D) The mother must have received the mutant p57 allele from her father, while the father must have received the mutant p57 allele from his mother.
E) Actually, there's something inconsistent here. Such phenotypes for the parents are not anticipated when an imprintable gene is involved.
cs Scanned with CamScanner
Transcribed Image Text:Question 17 Individuals with Beckwith-Wiedemann syndrome (Bws) develop sporadic tumors due to a mutation in an imprintable gene, p57, on chrornosome 11. Normally, p57 regulates the cell cycle. The imprint on p57 is such that only the maternal allele is expressed. A heterozygous normal couple has two children with BWS and one normal child. How is it possible that both parents have the mutant p57 allele to pass along, but these parents do not themselves show the cancerous phenotype? A) Each must have received the mutant p57 allele from their respective fathers. B) Each must have received the mutant p57 allele from their respective mothers. C) The mother must have received the mutant p57 allele from her mother, while the father must have received the mutant p57 allele from his father. D) The mother must have received the mutant p57 allele from her father, while the father must have received the mutant p57 allele from his mother. E) Actually, there's something inconsistent here. Such phenotypes for the parents are not anticipated when an imprintable gene is involved. cs Scanned with CamScanner
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