Acetyl-CoA is generated by E1 and E2 ... purpose of E3? (PDHC)
Acetyl-CoA is generated by E1 and E2 ... purpose of E3? (PDHC)
INTRODUCTION :
Acetyl-CoA - It is a enzyme which is involved in many biochemical reactions of proteins, carbohydrates and lipids metabolism. Its main function is to deliver the acetyl group to the citric acid cycle( or TCA cycle ) to be oxidized for energy production.
Acetyl CoA is a cofactor for pyruvate carboxylase, which is the first enzyme in the gluconeogenic pathway. Acetyl-CoA is produced in mitochondria through a number of intracellular reactions like oxidative decarboxylation of pyruvate; catabolism of some amino acids (e.g. tyrosine, leucine & lysine); and the β-oxidation of fatty acids
PDHC - It is known as Pyruvate dehydrogenase complex (PDHC / PDC) which is a mitochondrial enzyme complex which catalyzes the oxidative decarboxylation of pyruvate to the formation of Acetyl CoA, nicotinamide adenine dinucleotide (NADH), and CO2. This reaction is the main connection between anaerobic and aerobic cerebral energy metabolism.
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