A10. Which of the following statements is true for an E1 reaction? The rate of an E1 elimination reaction of an alkyl halide depends on the concentration of: the alkyl halide only the base only the product the alkyl halide and base A В C D

Q: What is the product of the reaction below?

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Q: 1. What would be the best base for performing the elimination reaction shown? 2. What major…

A: Given : structure of reactants  Tip : strong base prefer E2 reaction.

Q: Choose the reagent(s) that would be most likely to complete this reaction. 00 Br o A B с D E Į Į NBS…

A: In the above reaction , an alkene in converted into bromo alkane i.e. addition of HBr to a double is…

Q: Draw the product of nucleophilic substitution with attached neutral nucleophile. When the initial…

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Q: A hydrogen and the leaving group have to be antiperiplanar in which reaction? O E2 O inversion O SN1…

A: The leaving groups and hydrogen leave when from the given organic substrate if the reaction goes…

Q: What is the major product(s) 2 formed after the following sequence of reactions? A A В в C D D E E…

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Q: 4. Devise concise syntheses for the following transformations. Clearly show the reagent and product…

A: Based on the required number of steps involved in the given 4 questions, I'm providing the…

Q: 9. Fill in the reagents for each reaction. ОН ОН OH + en + en

A: Answer:- This question is answered by using the simple concept of chemical reactions of organic…

Q: CN CN NH3 CH;OH Br Br OCH3 not formed

A: A nucleophile is an electron rich species, which can donate electron density in the form of lone…

Q: Which of the following is a correct factor influencing SN2 reactions? Having a chlorine on the alkyl…

A: Second option (2) Protic solvents decrease the speed of an SN2 reaction.

Q: Choose the best reagents to complete the reaction shown below. HO I Br2 A H₂O 1. LiAlH4 B 2. H3O+…

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Q: Which carbon(s) will be protoned in an addition of HBr? 3. 6.

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Q: Which of the following alkyl halides is most reactive in E1 reactions? CH3 CH3 CH; -CH2-Br CH —С—Br…

A: E1 reactions are the elimination reacgions

Q: Br, + OCH3 H

A: When alkyl halide is treated with X-, substitution product   is obtained when X- acts as a…

Q: Draw the structure for products A and B in the two-step synthesis below. OH РСС 1. LDA, -78 °C…

A: PCC is a oxidising agent  It will convert alcohol into ketone  LDA is a base which abstracts the…

Q: What type of eliminaton reactions occur in this process? Br strong base

A: Given compound is 1,1 dibromo pentane.  It carry two bromide groups, which are highly good leaving…

Q: How does changing the base from −OH to H2O affect the rate of an E2 reaction?

A: The E2 reactions occur in a single step, which has only one transition state. The rate of E2…

Q: 1. Draw a reasonable mechanism for each of the following reactions OH P CI H;SO, ÓH OH HCI

A: In case of dehydration reaction, reaction goes through such a way in which if carbocation…

Q: Which reagent will be best to make the following transformations? Br OH OH Br II II А. PB13 PBR3…

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Q: What happens to the rate of the following SN2 reaction when the 3-iodopentane is doubled and the…

A: Rate = k[Substrate][Nucleophile]

Q: Recall that the Friedel-Crafts alkylation reaction forms a new C-C bond between an aromatic ring and…

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Q: For each of the following reactions, predict the major product. NaOH H20 1. NaH 2. О 3. HCI, H20, Д…

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Q: Rank the following alkyl halides in order of increasing E2 reactivity. Then do the same for E1…

A: The question is based on the concept of elimination reactions. We need to arrange reactants in…

Q: 3. What are the starting Reagents for this reaction? 10pts NaGEt EtOH Ph Name of reaction (2pts)

A: The given reaction involves the synthesis reaction of the alpha, beta unsaturated ketone using the…

Q: In the presence of a nucleophile, which of the following will most likely undergo conjugate…

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Q: 5. Which one of the following ions/molecule is the strongest nucleophile? CH -SH A В

A: Identify the strongest nucleophile from the given ions / molecules .

Q: One of these reactions to prepare a carboxylic acid from an alkyl chloride fails. Which? O O Ya CI…

A: Tertiary alkyl halide not give SN2 reaction.

Q: What is the major product of the following reaction? HCI III IV.

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Q: What is the best reagent for carrying out the reaction shown below? OA OB OC OD OCH3 ? Jooks OCH3 A…

A: Claisen condensation reaction is the base catalyzed condensation between two esters to form the…

Q: Select the correct product for the reaction. ol O a. O b. Oc O d. 0 e. ОН ОН ОН о Н 729 ОН 1. LiAIH4…

A: The objective is to determine the product formed by the given reaction. Ketones on reaction with…

Q: What is the product of the reaction below? OH OH он HO но он ???? HCI он LOH OH но HO но но- но A B

A: At first O-CH-OH hydroxy oxygen undergo protonation under acidic condition. Then ring oxygen readily…

Q: 30° Br Br Br Which of the following alkyl halide reacts the fastest in an E2 reaction? O IV Br IV

A: The compounds contain tert-butyl group. As this is very bulky group, it will prefer to stay in…

Q: Draw the major product of this reaction. Ignore inorganic byproducts. 1 I excess CH3NH2 I I CI I I I…

A: Acid chloride reacts with a amine to form amide.

Q: What is the major product of this reaction? A - because a ketone is a meta-director    A -…

A: In electrophilic aromatic substitution reaction, Electron releasing group directs the incoming…

Q: Choose the major organic product of the reaction. A В II C II D IV Br Br Br Br Br Br, Br Br 0°C Br…

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.