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a. Select the best option. This is an example of paracrine, or neuronal, or endocrine signaling. Explain why you selected this option. Glucose stimulates insulin gene expression in pancreatic beta cells within 2h of glucose treatment. You are investigating the role of the transcription factor, CBP, in the regulation of glucose- stimulated insulin gene expression. You are able to examine insulin mRNA levels with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the results as shown in the figure below. b. From the results in the figure to the left, describe briefly the possible role of the transcription + Glu factor, CBP, in regulation of glucose-stimulated insulin gene expression. Does CBP act as an activator or repressor? Why? + Glu - Glu - Glu Normal cells Cells lacking СВР You next examine the promoter region of the insulin gene, and determine the level of histone H4 acetylation with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the following results. c. From the resllts in the figure to the right, describe briefly the possible effect of CBP on histone + Glu acetylation, and chromatin structure in the insulin gene promoter region with/without glucose treatment. Insulin MRNA expression 4 acetylation

a. Select the best option. This is an example of paracrine, or neuronal, or endocrine signaling. Explain why you selected this option. Glucose stimulates insulin gene expression in pancreatic beta cells within 2h of glucose treatment. You are investigating the role of the transcription factor, CBP, in the regulation of glucose- stimulated insulin gene expression. You are able to examine insulin mRNA levels with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the results as shown in the figure below. b. From the results in the figure to the left, describe briefly the possible role of the transcription + Glu factor, CBP, in regulation of glucose-stimulated insulin gene expression. Does CBP act as an activator or repressor? Why? + Glu - Glu - Glu Normal cells Cells lacking СВР You next examine the promoter region of the insulin gene, and determine the level of histone H4 acetylation with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the following results. c. From the resllts in the figure to the right, describe briefly the possible effect of CBP on histone + Glu acetylation, and chromatin structure in the insulin gene promoter region with/without glucose treatment. Insulin MRNA expression 4 acetylation

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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2. Insulin is a protein hormone released by pancreatic beta cells in response to elevated levels of nutrients in the blood, and plays a key role in several different cell types. Insulin triggers the uptake of glucose, fatty acids and amino acids into liver, adipose tissue and muscle and promotes the storage of these nutrients in the form of glycogen, lipids and protein respectively. Failure to uptake and store nutrients results in diabetes. a. Select the best option. This is an example of paracrine, or neuronal, or endocrine signaling. Explain why you selected this option. Glucose stimulates insulin gene expression in pancreatic beta cells within 2h of glucose treatment. You are investigating the role of the transcription factor, CBP, in the regulation of glucose- stimulated insulin gene expression. You are able to examine insulin mRNA levels with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the results as shown in the figure below. b. From the results in the figure to the left, describe briefly the possible role of the transcription + Glu factor, CBP, in regulation of glucose-stimulated insulin gene expression. Does CBP act as an activator or repressor? Why? Glu Glu Glu Normal cells Cells lacking CBP You next examine the promoter region of the insulin gene, and determine the level of histone H4 acetylation with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the following results. c. From the resluts in the figure to the right, describe briefly the possible effect of CBP on histone Glu acetylation, and chromatin structure in the insulin gene promoter region with/without glucose treatment. Glu - Glu Glu Normal cells Cells lacking СВР Insulin MRNA expression Histone H4 acetylation
Transcribed Image Text:2. Insulin is a protein hormone released by pancreatic beta cells in response to elevated levels of nutrients in the blood, and plays a key role in several different cell types. Insulin triggers the uptake of glucose, fatty acids and amino acids into liver, adipose tissue and muscle and promotes the storage of these nutrients in the form of glycogen, lipids and protein respectively. Failure to uptake and store nutrients results in diabetes. a. Select the best option. This is an example of paracrine, or neuronal, or endocrine signaling. Explain why you selected this option. Glucose stimulates insulin gene expression in pancreatic beta cells within 2h of glucose treatment. You are investigating the role of the transcription factor, CBP, in the regulation of glucose- stimulated insulin gene expression. You are able to examine insulin mRNA levels with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the results as shown in the figure below. b. From the results in the figure to the left, describe briefly the possible role of the transcription + Glu factor, CBP, in regulation of glucose-stimulated insulin gene expression. Does CBP act as an activator or repressor? Why? Glu Glu Glu Normal cells Cells lacking CBP You next examine the promoter region of the insulin gene, and determine the level of histone H4 acetylation with/without glucose treatment in normal cells and mutant cells that lack the transcription factor, CBP, and obtain the following results. c. From the resluts in the figure to the right, describe briefly the possible effect of CBP on histone Glu acetylation, and chromatin structure in the insulin gene promoter region with/without glucose treatment. Glu - Glu Glu Normal cells Cells lacking СВР Insulin MRNA expression Histone H4 acetylation
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