Question one parts A though Hd. You have a plan to make the cellular signaling peptide RGD (Arg-Gly-Asp). If you are beginning fromthe Arginine (Arg) amino acid, which amino acid(s) will require NH2 protection to optimize thea. Look at the non-natural amino acid below and note that the pka's of particular groups are provided.synthesis?Determine the Isoelectric point of this amino acid (pl). Please answer as a letter choice only (i.e., "E"not "E)"A) All 3 amino acids will need NH2 protectionB) Gly and Asp will need NH2 protectionC) Arg and Gly will need NH2 protectionpka = 4.20 HOноКа 2.00HO,D) Only ArgNH,pКа 9.50E. Which of the following amino acids will not produce a purple color (indicative of 2 ninhydrinmolecules binding) when reacted with ninhydrin?A) pl = 6.20B) pl = 3.10A) phenylalanineC) pl = 5.23D) pl = 5.75B) valineC) prolineb. Which drawing best indicates the form of the amino acid at a pH of 8.4?D) histidineF. If you had a mixture of leucine, arginine, and glutamic acid in a pH of 6 and applied a drop onto paperconnected to an electrophoresis apparatus. Which of these would move toward the cathode (-).pka -2.00HO.pka = 4.20HOA) LeucineNH,pka -9.50B) ArginineC) Glutamic AcidA.В.D) None of themно,OHHO.G. True/False - Dicyclohexylcarbodiimide is a typical reagent in peptide synthesis for protectingNH,NH,carboxylic acid groups.C.D.H. True/False t-butoxycarbonyl dicarbonate (Boc20) adds a t-butoxy carbonyl group to the amineно.NH,NH3portion of the amino acid creating an amide (carbamate) and protects the amine portion from sidereactions.c. Which of the following dipeptides is leucinylserine?A.B.OHH,N.OHH,N.OHноD.C.OHHN.OHHN.онно

As per our company guidelines we are supposed to answer first 3 sub-parts. Kindly repost the other parts in next question.First we have to know about isoelectric point. # Isoelectric point : The pH at which there is no net migration of the amino acid under the influence of an applied electric field is called isoelectric point. It is represented as pI. At pI, [cation]=[anion](a) As the given amino acid is acidic(because it exist as cation that means overall positive charge is present on the given amino acid). Hence, isoelectric point of acidic amino acid can be calculated by taking the average of pKa values of two -COOH groups(uncharged) in its acidic form i.e. pKa of two -COOH groups are 4.20 and 2.00 respectively pI = 4.20+2.002 pI = 3.1 Hence, option (B) is the correct answer.(b) As the given pH is 8.4. Hence, this pH indicates that the amino acid will be basic in nature. Basic amino acids exist as anions that means there must be overall negative charge on the amino acid. Hence, Option (D) is the correct answer. Because, here overall negative charge is present on the amino acid.(c) It is not leucinylserine. In actual the dipeptide is leucylserine. Hence, Dipeptide given in option(A) is leucylserine. Molecular formula of leucylserine is C9H18N2O4 .

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a. Look at the non-natural amino acid below and note that the pka's of particular groups are provided. Determine the Isoelectric point of this amino acid (p). Please answer as a letter choice only (i.e, "E" not "E)" pka - 4.20 HO. pKa = 2.00 HO. NH, pka - 9.50 A) pl = 6.20 C) pl = 5.23 B) pl = 3.10 D) pl = 5.75 b. Which drawing best indicates the form of the amino acid at a pH of 8.4? pka4.20 pka2.00 NH, pka950 HO. NH, NH, c. Which of the following dipeptides is leucinyiserine? HN. но D. OH он OH HO

a. Look at the non-natural amino acid below and note that the pka's of particular groups are provided. Determine the Isoelectric point of this amino acid (p). Please answer as a letter choice only (i.e, "E" not "E)" pka - 4.20 HO. pKa = 2.00 HO. NH, pka - 9.50 A) pl = 6.20 C) pl = 5.23 B) pl = 3.10 D) pl = 5.75 b. Which drawing best indicates the form of the amino acid at a pH of 8.4? pka4.20 pka2.00 NH, pka950 HO. NH, NH, c. Which of the following dipeptides is leucinyiserine? HN. но D. OH он OH HO

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10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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The isoelectric point (pl) can best be calculated by: Averaging the sums of all pkas. Averaging the sum of the two pKas closest to physiological pH. Averaging the two pKas "sandwiching" the zwitterionic form. Averaging the two pKas of the alpha-amino and alpha-carboxy groups.
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NH₂ 4. Draw the following peptides. You may use Kelule Formula or the Line-bond (or skeletal) Formula: a. Alanine-Glycine-Serine b. Phe-Tyr-Trp C. KMH 5. Briefly describe the following: a. Primary Structure b. Secondary Structure NH₂ c. Tertiary Structure d. Quaternary Structure 6. APPLICATION: For the following items, do some literature search to answer them: a. Sickle cell anemia is one of the disease that is caused by defects in protein structure. Briefly discuss the biochemical basis of sickle cell anemia. What level of protein structure does it affect? b. Thalassemias are caused by genetic defects that impair the synthesis hemoglobin causing anemia symptoms to people affected by it. Briefly discuss the biochemical basis of thalassemias. What level of protein structure does it affect?
1 Submit Q10. !! Unanswered Q10. An average amino acid is about 110 Da (Daltons). If there are 1273 amino acids in the SARS-CoV-2 spike protein, what do you expect the mass of spike to be? How does that compare to the expected mass of about 200 KDa? more than expected by about 90 Da Less than expected by about 90 Da B. more than expected by by about 60 KDa less than expected by about 60 KDa Submit odf 0/11 answered
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Estimate the pl values of the following peptides: a. Ser-lle b. Gly-Tyr-Val
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