Question one parts A though Hd. You have a plan to make the cellular signaling peptide RGD (Arg-Gly-Asp). If you are beginning fromthe Arginine (Arg) amino acid, which amino acid(s) will require NH2 protection to optimize thea. Look at the non-natural amino acid below and note that the pka's of particular groups are provided.synthesis?Determine the Isoelectric point of this amino acid (pl). Please answer as a letter choice only (i.e., "E"not "E)"A) All 3 amino acids will need NH2 protectionB) Gly and Asp will need NH2 protectionC) Arg and Gly will need NH2 protectionpka = 4.20 HOноКа 2.00HO,D) Only ArgNH,pКа 9.50E. Which of the following amino acids will not produce a purple color (indicative of 2 ninhydrinmolecules binding) when reacted with ninhydrin?A) pl = 6.20B) pl = 3.10A) phenylalanineC) pl = 5.23D) pl = 5.75B) valineC) prolineb. Which drawing best indicates the form of the amino acid at a pH of 8.4?D) histidineF. If you had a mixture of leucine, arginine, and glutamic acid in a pH of 6 and applied a drop onto paperconnected to an electrophoresis apparatus. Which of these would move toward the cathode (-).pka -2.00HO.pka = 4.20HOA) LeucineNH,pka -9.50B) ArginineC) Glutamic AcidA.В.D) None of themно,OHHO.G. True/False - Dicyclohexylcarbodiimide is a typical reagent in peptide synthesis for protectingNH,NH,carboxylic acid groups.C.D.H. True/False t-butoxycarbonyl dicarbonate (Boc20) adds a t-butoxy carbonyl group to the amineно.NH,NH3portion of the amino acid creating an amide (carbamate) and protects the amine portion from sidereactions.c. Which of the following dipeptides is leucinylserine?A.B.OHH,N.OHH,N.OHноD.C.OHHN.OHHN.онно

As per our company guidelines we are supposed to answer first 3 sub-parts. Kindly repost the other parts in next question.First we have to know about isoelectric point. # Isoelectric point : The pH at which there is no net migration of the amino acid under the influence of an applied electric field is called isoelectric point. It is represented as pI. At pI, [cation]=[anion](a) As the given amino acid is acidic(because it exist as cation that means overall positive charge is present on the given amino acid). Hence, isoelectric point of acidic amino acid can be calculated by taking the average of pKa values of two -COOH groups(uncharged) in its acidic form i.e. pKa of two -COOH groups are 4.20 and 2.00 respectively pI = 4.20+2.002 pI = 3.1 Hence, option (B) is the correct answer.(b) As the given pH is 8.4. Hence, this pH indicates that the amino acid will be basic in nature. Basic amino acids exist as anions that means there must be overall negative charge on the amino acid. Hence, Option (D) is the correct answer. Because, here overall negative charge is present on the amino acid.(c) It is not leucinylserine. In actual the dipeptide is leucylserine. Hence, Dipeptide given in option(A) is leucylserine. Molecular formula of leucylserine is C9H18N2O4 .

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a. Look at the non-natural amino acid below and note that the pka's of particular groups are provided. Determine the Isoelectric point of this amino acid (p). Please answer as a letter choice only (i.e, "E" not "E)" pka - 4.20 HO. pKa = 2.00 HO. NH, pka - 9.50 A) pl = 6.20 C) pl = 5.23 B) pl = 3.10 D) pl = 5.75 b. Which drawing best indicates the form of the amino acid at a pH of 8.4? pka4.20 pka2.00 NH, pka950 HO. NH, NH, c. Which of the following dipeptides is leucinyiserine? HN. но D. OH он OH HO

a. Look at the non-natural amino acid below and note that the pka's of particular groups are provided. Determine the Isoelectric point of this amino acid (p). Please answer as a letter choice only (i.e, "E" not "E)" pka - 4.20 HO. pKa = 2.00 HO. NH, pka - 9.50 A) pl = 6.20 C) pl = 5.23 B) pl = 3.10 D) pl = 5.75 b. Which drawing best indicates the form of the amino acid at a pH of 8.4? pka4.20 pka2.00 NH, pka950 HO. NH, NH, c. Which of the following dipeptides is leucinyiserine? HN. но D. OH он OH HO

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10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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