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A. Consider the Pharmacokinetic (PK) profiles of the NRTI below and 1. Discuss the structural basis for the observed PKs 2. Discuss any other Pharmacokinetic profiles that you think might be different. Remember to provide a structural basis for your reasoning. 3. Discus and account for the differences in clinical use (indications) and Toxicities of the drugs below. Table 1 In vitro activity and stability of TFV and its prodrugs TDF and TAF. EC 50 HIV-1 (μM) Half-life (min) TFV 5.0 TDF TAF 0.05 0.005 stable 0.41 90

A. Consider the Pharmacokinetic (PK) profiles of the NRTI below and 1. Discuss the structural basis for the observed PKs 2. Discuss any other Pharmacokinetic profiles that you think might be different. Remember to provide a structural basis for your reasoning. 3. Discus and account for the differences in clinical use (indications) and Toxicities of the drugs below. Table 1 In vitro activity and stability of TFV and its prodrugs TDF and TAF. EC 50 HIV-1 (μM) Half-life (min) TFV 5.0 TDF TAF 0.05 0.005 stable 0.41 90

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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A. Consider the Pharmacokinetic (PK) profiles of the NRTI below and 1. Discuss the structural basis for the observed PKs 2. Discuss any other Pharmacokinetic profiles that you think might be different. Remember to provide a structural basis for your reasoning. 3. Discus and account for the differences in clinical use (indications) and Toxicities of the drugs below. Table 1 In vitro activity and stability of TFV and its prodrugs TDF and TAF. EC 50 HIV-1 (μM) Half-life (min) TFV 5.0 TDF TAF 0.05 0.005 stable 0.41 90
Transcribed Image Text:A. Consider the Pharmacokinetic (PK) profiles of the NRTI below and 1. Discuss the structural basis for the observed PKs 2. Discuss any other Pharmacokinetic profiles that you think might be different. Remember to provide a structural basis for your reasoning. 3. Discus and account for the differences in clinical use (indications) and Toxicities of the drugs below. Table 1 In vitro activity and stability of TFV and its prodrugs TDF and TAF. EC 50 HIV-1 (μM) Half-life (min) TFV 5.0 TDF TAF 0.05 0.005 stable 0.41 90
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