A. A study is conducted to test the hypothesis that people with glaucoma have higher-than-average blood pressure. The study includes 200 people with glaucoma whose mean Systolic Blood Pressure (SBP) is 140 mm Hg with a standard deviation of 25 mm Hg. If the average SBP for people of comparable age is 130 mm Hg, is there an association between glaucoma and blood pressure?

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Answer A1, B1, and B2:

A. A study is conducted to test the hypothesis that people with glaucoma have higher-than-average blood pressure. The study includes 200 people with glaucoma whose mean Systolic Blood Pressure (SBP) is 140 mm Hg with a standard deviation of 25 mm Hg.

    1. If the average SBP for people of comparable age is 130 mm Hg, is there an association between glaucoma and blood pressure?

B. Suppose we want to estimate the concentration (µg/mL) of a specific dose of ampicillin in the urine after various periods of time. We recruit 25 volunteers who have received ampicillin and find they have a mean concentration of 7.0 µg/mL with a standard deviation of 2.0 µg/mL. Assume the underlying population distribution of concentrations is normally distributed.

    1. Find the 95% CI for the population mean concentration.
    2. How large a sample would be needed to ensure that the length of the 95% CI is 0.5 µg/mL assuming the sample standard deviation remains at 2.0 µg/mL?
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