A study was recently published in Western Australia on the relationship between method of conception and prevalence of major birth defects (Hansen et al. [7]). The prevalence of at least one major birth defect among infants conceived naturally was 4.2%, based on a large sample of infants. Among 837 infants born as a result of in-vitro fertilization (IVF), 75 had at least one major birth defect. (1) Do an unusual number of infants have at least one birth defect in the IVF group? Why or why not? (Hint: Use an approximation to the binomial distribution.)

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A study was recently published in Western Australia on the
relationship between method of conception and prevalence
of major birth defects (Hansen et al. [7]).
The prevalence of at least one major birth defect among infants conceived naturally was 4.2%, based on a large sample of infants. Among 837 infants born as a result of in-vitro
fertilization (IVF), 75 had at least one major birth defect.

(1) Do an unusual number of infants have at least one
birth defect in the IVF group? Why or why not? (Hint: Use
an approximation to the binomial distribution.)

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