A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from compounds 2, 5 and 6. F30 OH F3C. OH H. H2N. Br (а) (b) NH2 1 3 но

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Describe a synthetic plan with justification of the sequence of reactions you would take to complete the synthesis of 1. Suggest reagents 

A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from
compounds 2, 5 and 6.
F3C
F3C
OH
H2N
N.
Br
A (a)
(b)
NH2
1
HO
6.
2.
Transcribed Image Text:A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from compounds 2, 5 and 6. F3C F3C OH H2N N. Br A (a) (b) NH2 1 HO 6. 2.
In order to complete the synthesis of 1 from compounds 2, 3, and 4, describe a
d)
synthetic plan with suitable justification of the sequence of reactions you would
undertake. Suggest suitable reagents for all your proposed reactions.
CF3
OH
OH
CF3
H2N
Br
H.
NH2
(1)
(3)
(4)
(2)
Transcribed Image Text:In order to complete the synthesis of 1 from compounds 2, 3, and 4, describe a d) synthetic plan with suitable justification of the sequence of reactions you would undertake. Suggest suitable reagents for all your proposed reactions. CF3 OH OH CF3 H2N Br H. NH2 (1) (3) (4) (2)
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