Consider a receptor (R) that binds two ligands (L & M ) in a sequential fashion. For example, ligand"L" must be present before ligand "M" can bind. In dissociation reactions, it would look like this.R•L•M R•L + M with equilibrium constant KamR•L OR+Lwith equilibrium constant Kaa. Derive an equation that relates the fraction [R•L•M]/[R]tot to the concentrations of free L and freeM.b. In terms of the dissociation constant, Kam, what concentration of ligand "M" will lead to 50% ofthe receptor existing in the R•L•M state when [L] = 10 x Ka?

a receptor equential nple, ligai L" must be present before ligand "M" can bind. In dissociation reactions, it would look like this. R•L•M R•L + M with equilibrium constant Kas with equilibrium constant Kdt R•L OR +L . Derive an equation that relates the fraction [R•L•M]/[R]tot to the concentrations of free L and fre М. . In terms of the dissociation constant, Kam, what concentration of ligand "M" will lead to 50% the receptor existing in the R•L•M state when [L] = 10 x Ka?

a receptor equential nple, ligai L" must be present before ligand "M" can bind. In dissociation reactions, it would look like this. R•L•M R•L + M with equilibrium constant Kas with equilibrium constant Kdt R•L OR +L . Derive an equation that relates the fraction [R•L•M]/[R]tot to the concentrations of free L and fre М. . In terms of the dissociation constant, Kam, what concentration of ligand "M" will lead to 50% the receptor existing in the R•L•M state when [L] = 10 x Ka?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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