A racemic mixture can be separated using chiral chromatography. An image of the stationary phase of a chiral chromatography column is shown below. Two enantiomers (Structure I and II) are moving through the column. Identify which compound will elute from the column without being attracted to the column. A) I B) II Structure Structure II Structure Structure Il O O O O C) Neither compound will elute. D) Both compounds will elute.

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**Title: Understanding Chiral Chromatography: Separation of Enantiomers**

**Introduction:**
A racemic mixture can be separated using chiral chromatography. This technique leverages the chirality of molecules to distinguish and separate enantiomers from each other. 

**Objective:**
To identify which compound (Structure I or Structure II) will elute from the column without being attracted to the stationary phase of a chiral chromatography column.

**Description of Diagram:**
The diagram visually represents the stationary phase of a chiral chromatography column with two enantiomers, Structure I and Structure II, moving through it. The stationary phase consists of chiral selectors that interact differently with each enantiomer.

**Diagram Analysis:**
1. **Composition of the Stationary Phase:**
   - The stationary phase is populated with chiral selector molecules.
   - Each selector molecule appears to have distinct binding sites represented by different colors and shapes (e.g., blue circle, red oval).

2. **Interaction with Enantiomers:**
   - Structure I and Structure II enantiomers interact with the selectors in the column:
     - Structure I does not seem to bind or interact significantly with the selectors, allowing it to move through the column freely.
     - Structure II interacts and binds more strongly with the chiral selector molecules, indicated by consistent attachment points along the path.

**Question:**
Identify which compound will elute from the column without being attracted to the column.

**Answer Choices:**
A) I  
B) II  
C) Neither compound will elute.  
D) Both compounds will elute.  

Based on the diagram, the following conclusion can be drawn:

- **Answer: A) I**  
  Structure I will elute from the column without being attracted to the stationary phase.

**Conclusion:**
Understanding the interaction between chiral selectors and different enantiomers in a chiral chromatography column is crucial for effectively separating them. Enantiomers that interact less with the stationary phase will elute faster, while those that interact more will be retained longer in the column.
Transcribed Image Text:**Title: Understanding Chiral Chromatography: Separation of Enantiomers** **Introduction:** A racemic mixture can be separated using chiral chromatography. This technique leverages the chirality of molecules to distinguish and separate enantiomers from each other. **Objective:** To identify which compound (Structure I or Structure II) will elute from the column without being attracted to the stationary phase of a chiral chromatography column. **Description of Diagram:** The diagram visually represents the stationary phase of a chiral chromatography column with two enantiomers, Structure I and Structure II, moving through it. The stationary phase consists of chiral selectors that interact differently with each enantiomer. **Diagram Analysis:** 1. **Composition of the Stationary Phase:** - The stationary phase is populated with chiral selector molecules. - Each selector molecule appears to have distinct binding sites represented by different colors and shapes (e.g., blue circle, red oval). 2. **Interaction with Enantiomers:** - Structure I and Structure II enantiomers interact with the selectors in the column: - Structure I does not seem to bind or interact significantly with the selectors, allowing it to move through the column freely. - Structure II interacts and binds more strongly with the chiral selector molecules, indicated by consistent attachment points along the path. **Question:** Identify which compound will elute from the column without being attracted to the column. **Answer Choices:** A) I B) II C) Neither compound will elute. D) Both compounds will elute. Based on the diagram, the following conclusion can be drawn: - **Answer: A) I** Structure I will elute from the column without being attracted to the stationary phase. **Conclusion:** Understanding the interaction between chiral selectors and different enantiomers in a chiral chromatography column is crucial for effectively separating them. Enantiomers that interact less with the stationary phase will elute faster, while those that interact more will be retained longer in the column.
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