A non-spontaneous reaction may be driven by coupling it to a reaction that is spontaneous. The formation of glutamine from glutamate and ammonium ions requires 14.2 kJ mol of energy input. It is driven by the hydrolysis of ATP to ADP mediated by the enzyme glutamine synthetase. (a) Given that the change in Gibbs energy for the hydrolysis of ATP corresponds to AG=-31 kJ mo under the conditions prevailing in a typical cell, can the hydrolysis drive the formation of glutamine? (b) How many moles of ATP must be hydrolyzed to form 1 mol glutamine?
A non-spontaneous reaction may be driven by coupling it to a reaction that is spontaneous. The formation of glutamine from glutamate and ammonium ions requires 14.2 kJ mol of energy input. It is driven by the hydrolysis of ATP to ADP mediated by the enzyme glutamine synthetase. (a) Given that the change in Gibbs energy for the hydrolysis of ATP corresponds to AG=-31 kJ mo under the conditions prevailing in a typical cell, can the hydrolysis drive the formation of glutamine? (b) How many moles of ATP must be hydrolyzed to form 1 mol glutamine?
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Transcribed Image Text:A non-spontaneous reaction may be driven by coupling it to a reaction that is spontaneous. The
formation of glutamine from glutamate and ammonium ions requires 14.2 kJ mol of energy input. It
is driven by the hydrolysis of ATP to ADP mediated by the enzyme glutamine synthetase.
(a) Given that the change in Gibbs energy for the hydrolysis of ATP corresponds to AG=-31 kJ
mo under the conditions prevailing in a typical cell, can the hydrolysis drive the formation
of glutamine?
(b) How many moles of ATP must be hydrolyzed to form 1 mol glutamine?
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