A chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug for the control of gastric acidity and peptic ulcers. Cimetidine reduces gastric acid secretion by inhibiting the interaction of histamine with gastric H, recep- tors. In the development of this drug, a cyano group was added to the substituted gua- nidino group to alter its basicity. Do you expect this modified guanidino group to be more basic or less basic than the guanidino group of arginine? Explain. N-CN H,C CH,SCH,CH,NHËNHCH, HN, Cimetidine (Tagamet)

A chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug for the control of gastric acidity and peptic ulcers. Cimetidine reduces gastric acid secretion by inhibiting the interaction of histamine with gastric H, recep- tors. In the development of this drug, a cyano group was added to the substituted gua- nidino group to alter its basicity. Do you expect this modified guanidino group to be more basic or less basic than the guanidino group of arginine? Explain. N-CN H,C CH,SCH,CH,NHËNHCH, HN, Cimetidine (Tagamet)

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

Lysine and tryptophan are two amino acids that contain an additional N atom in the R group bonded to the α carbon. While lysine is classified as a basic amino acid because it contains an additional basic N atom, tryptophan is classified as a neutral amino acid. Explain why this difference in classification occurs.
Researchers analysed a glycopeptide (a peptide carrying one or several oligosaccharide groups) and determined both the sequence of the peptide and the sequence of the sugar molecule. The latter was identified as a diholoside coupled to the peptide by an osidic bond. The systematic name of this sugar is: B-D-glucopyranosyl-(1→4)-ß-D-galactopyranose. : Represent the chemical formula of this diholoside in a way that all oses are Question 1 represented according to the Haworth convention. Apart from the furane and/or pyrane cycles all atoms of this molecule must be given.
When adding formaldehyde solution to gamma-aminobutyric acid: A) The amino group reacts B) The connection has basic properties blocked C) Carboxyl group reacts with formaldehyde D) The compound is blocked by acidic properties
Treating chitin with H2O, −OH hydrolyzes its amide linkages, forming a compound called chitosan. What is the structure of chitosan? Chitosan has been used in shampoos, fibers for sutures, and wound dressings.
Ethyleneimine reacts with cysteine side chains in proteins to form S - aminoethyl derivatives. The peptide bonds on the carboxyl side of these modified cysteine residues are susceptible to hydrolysis by trypsin . Why?
write the IUPAC names for the following aminos CH,CH, CH;CH,NH2 b) CH;CH, c) CH 9. Escriha la aetunt -.
What is the structure of each amino acid at its isoelectric point: (a) alanine; (b) methionine; (c) aspartic acid; (d) lysine?
Brucine is a poisonous alkaloid obtained from Strychnos nux vomica, a tree that grows in India, Sri Lanka, and northern Australia. Write out a resolution scheme similar to the one given in Section 29.3A, which shows how a racemic mixture of phenylalanine can be resolved using brucine.
A biochemist completely digests a glycerophospholipid with a mixture of phospholipases A and D. HPLC and mass spectrometry analysis reveals the presence of an amino acid of 105,09 Da, a saturated fatty acid of 256.43 Da, and an omega-3 monounsaturated fatty acid of 282.45 Da. Which amino acid does the glycerophospholipid contain? O valine (C,H, NO,) O alanine (C, H,NO,) O scrine (C,H,NO,) O proline (C,H,NO,) Modify the phosphoglycerol backbone to draw the most likely structure of the lipid. Add the amino acid using the groups tool. Draw Rings Groups More Erase Select