What is your z-test statistic? A case-control study of patients on antihypertensive drugs related an increased risk of myocardial infarction (MI) for patients using calcium channel blockers. In this study, cases wereantihypertensive drug patients who had suffered a first fatal or nonfatal MI through 1993, and controls were antihypertensive drug patients, matched by demographic factors, who had notsuffered a MI. Among the comparisons reported were patients receiving calcium channel (CC) blockers (with and without diuretics) and patients receiving B-blockers (with and withoutdiuretics). Results of numbers of patient by drug/MI status combination are given in the following table.AntihypertensiveO HO: p1=p2 vs. Ha: p1 < p2O HO: p1> p2 vs. Ha: p1=p2DrugDoes it appear that an increased risk of myocardial infarction (MI) is related to using calcium channel (CC) blockers? The case-control nature of this study requires we compare theproportion of CC blocker users among those had MI attack (p1) vs. the proportion of CC blocker users among those had no MI (p2).What is your hypothesis for this test?O HO: p1p2 vs. Ha: p1=p2CC blockerB-blockerO HO: p1=p2 vs. Ha: p1 > p2Occurrence ofYes (cases)8085Myocardial InfarctionNo (controls)230395

Given that: Occurrence of Myocardial Infraction Yes (cases) No (controls) Antihypertensive CC-blocker 80 230 Drug β-blocker 85 395Find the sample proportions of CC-blocker users among those had MI attack and those had no MI attack by using the formulas: p^1=x1n1 and p^2=x2n2 Here, x1=80 and x2=230 The sample sizes of each group is: n1=80+85=165 and n2=230+395=625 Calculation for sample proportions: p^1=x1n1=80165=0.485 p^2=x2n2=230625=0.368 State the null and alternative hypotheses: H0:p1=p2H1:p1>p2 Thus, Option (4) is the correct answer. Compute the pooled proportion by using the formula: p¯=x1+x2n1+n2=80+230165+625=0.392Compute the z-test statistic by using the formula: z=p^1-p^2-p1-p2p¯1-p¯1n1+1n2=0.485-0.368-00.3921-0.3921165+1625=2.738 Thus, the required test statistic is 2.738.