A C. elegans (nematode) gene called par-1 helps todetermine the AP axis of the animal early in development. Scientists determined that par-1 is pleiotropic—it also has a later function in forming the vulva of theadult animal. How could researchers circumvent thelethality of par-1− mutants to observe the later function of the par-1 gene? (Hint: C. elegans larvae caneat bacteria expressing RNAi for any gene.)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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A C. elegans (nematode) gene called par-1 helps to
determine the AP axis of the animal early in development. Scientists determined that par-1 is pleiotropic—
it also has a later function in forming the vulva of the
adult animal. How could researchers circumvent the
lethality of par-1− mutants to observe the later function of the par-1 gene? (Hint: C. elegans larvae can
eat bacteria expressing RNAi for any gene.)

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