a) Based on the above case description, what would you expect for the lab results for this child? Choose: Higher than normal range, Lower than normal range, or Normal range for each result.   Neutrophils __________ Eosinophils __________ CD20 + cells __________ CD4 + cells __________ CD8 + cells __________

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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A 18 month old male is brought to the Emergency room with fever, irritability, and a cough. A sputum sample obtained for culture and gram stain revealed pneumonia caused by Streptococcus pneumonia. He was breast fed until 6 months of age and had no signs of infection until 9 months of age, at which point he had several recurrent ear infections and sinusitis caused by Haemophilus influenzae. He is up to date on all immunizations. Blood was taken for hematological analysis, and genetic testing revealed that the child carries a mutation in the tyrosine kinase, Btk.

 

a) Based on the above case description, what would you expect for the lab results for this child? Choose: Higher than normal range, Lower than normal range, or Normal range for each result.

 

Neutrophils __________

Eosinophils __________

CD20 + cells __________

CD4 + cells __________

CD8 + cells __________

Serum immunoglobulin IgM ________

Serum immunoglobulin IgG ________

Serum immunoglobulin IgA ________

b) Describe the phenotype that a person carrying a Btk mutation would be expected to show. For each of the choices you indicated above, provide an explanation for how a Btk mutation factored into your choice.

 

c) Explain why this child is susceptible to infections with organisms such as Streptococcus pneumonia and Haemophilus influenzae. In your answer, include a description of the primary virulence factor of these organisms that would make this child susceptible.

 

d) Based on what you know about how vaccines work, would you additional boosters of the pneumococcal and H. influenzae vaccines for this child? Provide an explanation for your answer.

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