Mycophenolate mofetil was administered for 1 month after the intravenous injection of donor cells. The patient was hospitalized on day 21 because of fever with neutropenia and was discharged on day 23 Blood cultures were negative, but the fever rapidly resolved after antibiotics were administered. The patient had no further hospitalizations. Two kidney-biopsy specimens were obtained according to an outpatient protocol at 3 and 12 months. Cyclosporine was gradually tapered and was discontinued 6 months after the transplantation. During those 6 months, there were neither rejection episodes nor clinical manifestations of acute or chronic graft-versus-host disease, and the chimerism was persistent. The patient returned to work about 3 months after the transplantation, and graft biopsy specimens showed normal kidney tissue, no cellular infiltrates were seen. The patient remains in good health 34 months after transplantation. Why would the patient show neutropenia?
Mycophenolate mofetil was administered for 1 month after the intravenous injection of donor cells. The patient was hospitalized on day 21 because of fever with neutropenia and was discharged on day 23 Blood cultures were negative, but the fever rapidly resolved after antibiotics were administered. The patient had no further hospitalizations. Two kidney-biopsy specimens were obtained according to an outpatient protocol at 3 and 12 months. Cyclosporine was gradually tapered and was discontinued 6 months after the transplantation. During those 6 months, there were neither rejection episodes nor clinical manifestations of acute or chronic graft-versus-host disease, and the chimerism was persistent. The patient returned to work about 3 months after the transplantation, and graft biopsy specimens showed normal kidney tissue, no cellular infiltrates were seen. The patient remains in good health 34 months after transplantation. Why would the patient show neutropenia?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Mycophenolate mofetil was administered for 1 month after the intravenous injection of donor
cells. The patient was hospitalized on day 21 because of fever with neutropenia and was
discharged on day 23 Blood cultures were negative, but the fever rapidly resolved after
antibiotics were administered. The patient had no further hospitalizations. Two kidney-biopsy
specimens were obtained according to an outpatient protocol at 3 and 12 months. Cyclosporine
was gradually tapered and was discontinued 6 months after the transplantation. During those 6
months, there were neither rejection episodes nor clinical manifestations of acute or chronic
graft-versus-host disease, and the chimerism was persistent. The patient returned to work about
3 months after the transplantation, and graft biopsy specimens showed normal kidney tissue, no
cellular infiltrates were seen. The patient remains in good health 34 months after
transplantation.
Why would the patient show neutropenia?
Explain what the two graphs below show about the success or failure of the transplant.
yang
Serum Cine
100-
200
400
600
200
400
600
Days since Kidney Transplantation
Grandates
abo
cells
800
Feafls
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