A 64-year-old man goes to his local primary health care centre because he has become increasingly overweight. He has gained 8 kg over the past 6 months. The patient presented with rounded face, thin skin and poor wound healing. Lab diagnosis showed high levels of adrenocorticotropic hormone. The high level of adrenocorticotropic hormone specifically increases the secretion of: Glucocorticoids O Thyroid hormone O Growth hormone O None of the above O
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- A 12-year-old boy is brought to the physician because of increased urination and progressive fatigue during the past two weeks. Vital signs are within normal limits except for a pulse of 120/min. Physical examination shows dry skin and mucous membranes. His fasting serum glucose concentration is 350 mg/dL. The patient improves after insulin treatment. Which of the following best describes the effect of insulin binding to the insulin receptor (IR) on the surface of hepatocytes in this patient? a. Activation of serine/threonine kinase activity of the IR b. Down regulation of phosphoenolpyruvate carboxykinase c. Inactivation of ras d. Inhibition of glucose-transporter-4 (GLUT-4) translocation to the cell membrane e. Inhibition of phosphatidylinositol-3-kinase signaling pathwayOne of the indications for prescribing nateglinide is:A. Depletion of pancreatic beta-cellsB. Significant postprandial hyperglycemiaC. Tendency to develop lactic acidosisD. Resistance to sulfonylureasE. Insulin resistanceA 24-year old female showed high concentration of growth hormone. Oral glucose tolerance test was performed but failed to lower the high levels of her growth hormone. This patient could suffer from: Cushing's disease O Addison's disease O Acromegaly O Goiter O
- Write the name of the endocrine gland that secretes the following hormones. Hormone Endocrine Gland 1. ACTH 2. ADH 3. aldosterone 4. androgens (DHEA) 5. calcitonin 6. cortisol; cortisone 7. epinephrine/NE 8. estrogen; progesterone 9. FSH 10. glucagon 11. hGH 12. insulin 13. LH 14. melatonin 15. OT 16. PRL 17. PTH 18. T 3 and T4 19. testosterone 20. TSH 21. thymosin 22. MSHA 32-year-old male with type 1 diabetes since the age of 14 years was taken to the emergency department because of drowsiness, fever, cough, diffuse abdominal pain, and vomiting. Fever and cough started 2 days ago and the patient could not eat or drink water. He has been treated with an intensive insulin regimen (insulin glargine 24 IU at bedtime and a rapid-acting insulin analog before each meal). On examination he was tachypneic, his temperature was 39° C (102.2° F), pulse rate 104 beats per minute, respiratory rate 24 breaths per minute, blood pressure 100/70 mmHg; he also had dry mucous membranes, poor skin turgor, and rales in the right lower chest. He was slightly confused. Rapid hematology and biochemical tests showed hematocrit 48%, hemoglobin 14.3 g/dl (143 g/L), white blood cell count 18,000/ μ l, glucose 450 mg/dl (25.0 mmol/L), urea 60 mg/dl (10.2 mmol/L), creatinine 1.4 mg/dl (123.7 μ mol/L), Na+ 152 mEq/L, K+ 5.3 mEq/L, PO4 3−2.3 mEq/L (0.74 mmol/L), and Cl− 110 mmol/L.…A 32-year-old male with type 1 diabetes since the age of 14 years was taken to the emergency department because of drowsiness, fever, cough, diffuse abdominal pain, and vomiting. Fever and cough started 2 days ago and the patient could not eat or drink water. He has been treated with an intensive insulin regimen (insulin glargine 24 IU at bedtime and a rapid-acting insulin analog before each meal). On examination he was tachypneic, his temperature was 39° C (102.2° F), pulse rate 104 beats per minute, respiratory rate 24 breaths per minute, blood pressure 100/70 mmHg; he also had dry mucous membranes, poor skin turgor, and rales in the right lower chest. He was slightly confused. Rapid hematology and biochemical tests showed hematocrit 48%, hemoglobin 14.3 g/dl (143 g/L), white blood cell count 18,000/ μ l, glucose 450 mg/dl (25.0 mmol/L), urea 60 mg/dl (10.2 mmol/L), creatinine 1.4 mg/dl (123.7 μ mol/L), Na+ 152 mEq/L, K+ 5.3 mEq/L, PO4 3−2.3 mEq/L (0.74 mmol/L), and Cl− 110 mmol/L.…
- A 32-year-old male with type 1 diabetes since the age of 14 years was taken to the emergency department because of drowsiness, fever, cough, diffuse abdominal pain, and vomiting. Fever and cough started 2 days ago and the patient could not eat or drink water. He has been treated with an intensive insulin regimen (insulin glargine 24 IU at bedtime and a rapid-acting insulin analog before each meal). On examination he was tachypneic, his temperature was 39° C (102.2° F), pulse rate 104 beats per minute, respiratory rate 24 breaths per minute, blood pressure 100/70 mmHg; he also had dry mucous membranes, poor skin turgor, and rales in the right lower chest. He was slightly confused. Rapid hematology and biochemical tests showed hematocrit 48%, hemoglobin 14.3 g/dl (143 g/L), white blood cell count 18,000/ μ l, glucose 450 mg/dl (25.0 mmol/L), urea 60 mg/dl (10.2 mmol/L), creatinine 1.4 mg/dl (123.7 μ mol/L), Na+ 152 mEq/L, K+ 5.3 mEq/L, PO4 3−2.3 mEq/L (0.74 mmol/L), and Cl− 110 mmol/L.…What is the bodily impact of a decrease or lack of secretion of each hormone listed. 1. Thyrotropin 2. Corticotropin 3. Gonadotropin 4. Growth hormone releasing hormone 5. Growth hormone inhibiting hormone 6. Prolactin releasing hormone 7. Prolactin inhibiting hormones 8. Vasopressin 9. OxytocinWhat is the main cause of Cushing disease?A. Hypersecretion of corticotropinB. TuberculosisC. Adrenocortical carcinomaD. Autoimmune adrenalitisE. Hypersecretion of catecholamines
- The patient has a history of diabetes mellitus type 1. What effect might her prednisone prescription have on her diabetes? What actions are needed to reduce this effect?Explain in brief sentences please thank u The patient’s diagnosis is diabetes insipidus. The patient is confused about the difference between his condition and diabetes mellitis. How would you briefly explain the difference to him?Patient is a 55 year old female with a diagnosis of diabetes. She was diagnosed when she was 50 aftershe changed jobs and became more sedentary and which also resulted in a poor diet. She currentlyoverweight with a BMI of 32.Allergies NKDACurrent MedicationsMetformin 1000 mg BIDLisinopril 10 mg once dailyPMH Propranolol 10 mg TIDDMHTN1. What role does Lisinopril have in patients with DM