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A 12-year-old boy is brought to the physician because of increased urination and progressive fatigue during the past two weeks. Vital signs are within normal limits except for a pulse of 120/min. Physical examination shows dry skin and mucous membranes. His fasting serum glucose concentration is 350 mg/dL. The patient improves after insulin treatment. Which of the following best describes the effect of insulin binding to the insulin receptor (IR) on the surface of hepatocytes in this patient? a. Activation of serine/threonine kinase activity of the IR b. Down regulation of phosphoenolpyruvate carboxykinase c. Inactivation of ras d. Inhibition of glucose-transporter-4 (GLUT-4) translocation to the cell membrane e. Inhibition of phosphatidylinositol-3-kinase signaling pathway

A 12-year-old boy is brought to the physician because of increased urination and progressive fatigue during the past two weeks. Vital signs are within normal limits except for a pulse of 120/min. Physical examination shows dry skin and mucous membranes. His fasting serum glucose concentration is 350 mg/dL. The patient improves after insulin treatment. Which of the following best describes the effect of insulin binding to the insulin receptor (IR) on the surface of hepatocytes in this patient? a. Activation of serine/threonine kinase activity of the IR b. Down regulation of phosphoenolpyruvate carboxykinase c. Inactivation of ras d. Inhibition of glucose-transporter-4 (GLUT-4) translocation to the cell membrane e. Inhibition of phosphatidylinositol-3-kinase signaling pathway

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A 12-year-old boy is brought to the physician because of increased urination and progressive fatigue during the past two weeks. Vital signs are within normal limits except for a pulse of 120/min. Physical examination shows dry skin and mucous membranes. His fasting serum glucose concentration is 350 mg/dL. The patient improves after insulin treatment. Which of the following best describes the effect of insulin binding to the insulin receptor (IR) on the surface of hepatocytes in this patient? a. Activation of serine/threonine kinase activity of the IR b. Down regulation of phosphoenolpyruvate carboxykinase c. Inactivation of ras d. Inhibition of glucose-transporter-4 (GLUT-4) translocation to the cell membrane e. Inhibition of phosphatidylinositol-3-kinase signaling pathway
Transcribed Image Text:A 12-year-old boy is brought to the physician because of increased urination and progressive fatigue during the past two weeks. Vital signs are within normal limits except for a pulse of 120/min. Physical examination shows dry skin and mucous membranes. His fasting serum glucose concentration is 350 mg/dL. The patient improves after insulin treatment. Which of the following best describes the effect of insulin binding to the insulin receptor (IR) on the surface of hepatocytes in this patient? a. Activation of serine/threonine kinase activity of the IR b. Down regulation of phosphoenolpyruvate carboxykinase c. Inactivation of ras d. Inhibition of glucose-transporter-4 (GLUT-4) translocation to the cell membrane e. Inhibition of phosphatidylinositol-3-kinase signaling pathway
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