A 53-year-old man is referred to a neurologist because he is beginning to develop spastic- like movements in his lower limbs. Magnetic resonance imaging of the head shows loss of mass in the caudate nucleus, and a presumptive diagnosis of Huntington disease is made. The genetic basis of this disease is best described as which of the following? A Triple repeat expansion Nucleotide deletion

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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A 53-year-old man is referred to a
neurologist because he is beginning to
develop spastic- like movements in his
lower limbs. Magnetic resonance imaging
of the head shows loss of mass in the
caudate nucleus, and a presumptive
diagnosis of Huntington disease is made.
The genetic basis of this disease is best
described as which of the following?
A Triple repeat expansion
Nucleotide deletion
C
Point mutation
D Transposition of genetic material O
E DNA methylation
Transcribed Image Text:A 53-year-old man is referred to a neurologist because he is beginning to develop spastic- like movements in his lower limbs. Magnetic resonance imaging of the head shows loss of mass in the caudate nucleus, and a presumptive diagnosis of Huntington disease is made. The genetic basis of this disease is best described as which of the following? A Triple repeat expansion Nucleotide deletion C Point mutation D Transposition of genetic material O E DNA methylation
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