A 50-year-old patient was hospitalized in the infectious department of the district hospital on the 4th day of illness with suspected typhoid-paratyphoid disease. The disease began with a gradual rise in temperature, which reached a maximum level of 39 degrees C on the 3rd day. Complaints of headache, loss of appetite, general weakness, constipation, bloating and flatulence. From the anamnesis: a family member of the patient 2 months ago fell ill with typhoid fever. Objectively: remitting fever, pale skin, moderately bloated abdomen, slight enlargement of the liver and spleen, mental retardation. There is no rash. 1-What serological tests should be used to establish the etiology of typhoid? 2-What are the features of serological diagnosis in the early stages of the disease? What measures should be taken to avoid false-negative serological results in the early stages? 3-What serological reactions are used for serological diagnosis of typhoid fever and paratyphoid fever? Compare and evaluate the reactions used to determine the level of immunoglobulins in the serum, by specificity and sensitivity
A 50-year-old patient was hospitalized in the infectious department of the district hospital on the 4th day of illness with suspected typhoid-paratyphoid disease. The disease began with a gradual rise in temperature, which reached a maximum level of 39 degrees C on the 3rd day. Complaints of headache, loss of appetite, general weakness, constipation, bloating and flatulence. From the anamnesis: a family member of the patient 2 months ago fell ill with typhoid fever.
Objectively: remitting fever, pale skin, moderately bloated abdomen, slight enlargement of the liver and spleen, mental retardation. There is no rash.
1-What serological tests should be used to establish the etiology of typhoid?
2-What are the features of serological diagnosis in the early stages of the disease? What measures should be taken to avoid false-negative serological results in the early stages?
3-What serological reactions are used for serological diagnosis of typhoid fever and paratyphoid fever? Compare and evaluate the reactions used to determine the level of immunoglobulins in the serum, by specificity and sensitivity
Step by step
Solved in 3 steps
