(a) 2,3-Bisphosphoglycerate (BPG) reduces binding of O₂ to hemoglobin from almost hyperbolic to sigmoidal shape by stabilizing the T state. (b) CO2 is an end product of cellular respiration that is transported by Hb from tissue to lungs in the form of a carbamate moiety. (c) Four molecules of BPG bind to one molecule of hemoglobin. (d) Both H+ and CO₂ bind in a manner inversely related to the binding of O₂ (e) CO2 binds as a carbamate group to the a amino group at the amino terminal end of each Hb chain.
(a) 2,3-Bisphosphoglycerate (BPG) reduces binding of O₂ to hemoglobin from almost hyperbolic to sigmoidal shape by stabilizing the T state. (b) CO2 is an end product of cellular respiration that is transported by Hb from tissue to lungs in the form of a carbamate moiety. (c) Four molecules of BPG bind to one molecule of hemoglobin. (d) Both H+ and CO₂ bind in a manner inversely related to the binding of O₂ (e) CO2 binds as a carbamate group to the a amino group at the amino terminal end of each Hb chain.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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