9. Januvia is the trade name for sitagliptin, a drug that increases the body's ability to lower blood sugar levels, and thus it was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain why the fi ve-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside? CF3 F NH2 Ô sitagliptin

9. Januvia is the trade name for sitagliptin, a drug that increases the body's ability to lower blood sugar levels, and thus it was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain why the fi ve-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside? CF3 F NH2 Ô sitagliptin

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Quantum Mechanical Treatment of the Valence Bond Theory

Quantum mechanical treatment of valence bond theory refers to the relationship established between the quantum mechanical theory and the valence bond theory to describe the chemical bonding in a particular molecule.

Question

9. Januvia is the trade name for sitagliptin, a drug that increases the body's ability to lower
blood sugar levels, and thus it was introduced in 2006 for the treatment of type 2 diabetes. (a)
Explain why the fi ve-membered ring in sitagliptin is aromatic. (b) Determine the hybridization
of each N atom. (c) In what type of orbital does the lone pair on each N atom reside?
CF3
F
.N
NH, Ô
F
sitagliptin

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