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9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...

9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...
Transcribed Image Text:9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...
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