Homework Help is Here – Start Your Trial Now!
Science
Chemistry
9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...

9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
See similar textbooks
icon
Related questions
Question
Past paper question
9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...
Transcribed Image Text:9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...
Expert Solution
steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY
SEE MORE TEXTBOOKS