8. How many grams of sodium chloride should be used in compounding the prescription below? R Salt B chloride Sodium chloride Purified water ad 2% A. 0.174 g B. 0.270 g C. 0.150 g D. 0.550 g q.s. 30 mL Make isotonic solution Sig. Use as directed in the eye. E-value of Salt B is 0.20

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Chapter1: Chemical Foundations
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**Question:**

8. How many grams of sodium chloride should be used in compounding the prescription below?
- **R**
  - Salt B chloride          2%
  - Sodium chloride          q.s.
  - Purified water ad       30 mL
  - Make isotonic solution
  - Sig. Use as directed in the eye.
- **E-value of Salt B is 0.20**

**Options:**
- A. 0.174 g
- B. 0.270 g
- C. 0.150 g
- D. 0.550 g

---

**Explanation:**

To create an isotonic solution for ophthalmic use, the E-value of the active ingredient (Salt B) is considered. The goal is to achieve a solution that matches the osmotic pressure of body fluids. The E-value indicates the sodium chloride equivalent: how much sodium chloride 1 gram of the drug is equivalent to in terms of tonicity.

1. Calculate the amount of sodium chloride needed for tonicity.
2. Consider the percentage and E-value provided.
3. Use these to determine the appropriate option that represents the correct weight in grams of sodium chloride required.
Transcribed Image Text:**Question:** 8. How many grams of sodium chloride should be used in compounding the prescription below? - **R** - Salt B chloride 2% - Sodium chloride q.s. - Purified water ad 30 mL - Make isotonic solution - Sig. Use as directed in the eye. - **E-value of Salt B is 0.20** **Options:** - A. 0.174 g - B. 0.270 g - C. 0.150 g - D. 0.550 g --- **Explanation:** To create an isotonic solution for ophthalmic use, the E-value of the active ingredient (Salt B) is considered. The goal is to achieve a solution that matches the osmotic pressure of body fluids. The E-value indicates the sodium chloride equivalent: how much sodium chloride 1 gram of the drug is equivalent to in terms of tonicity. 1. Calculate the amount of sodium chloride needed for tonicity. 2. Consider the percentage and E-value provided. 3. Use these to determine the appropriate option that represents the correct weight in grams of sodium chloride required.
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