8. Answer all parts of this question. The synthesis of the drug minoxidil is shown below. Minoxidil is a K* channel opener and vasodilator used in the treatment of hair loss. NH2 POCI3 NH3 HN NH N [6] CI CI [7] CI NH2 (13) (14) [8] MCPBA NH2 H. NH2 NH2 [9] CI NH2 (15) Minoxidil The synthesis of compound (13) is achieved using three molar equivalents of phosphoryl chloride. This reaction [6] proceeds via a mechanism similar to that seen in the Vilsmeier reaction. Provide a complete mechanism for the substitutions of all three oxygens. What is the driving force for this reaction [6]? (a)

8. Answer all parts of this question. The synthesis of the drug minoxidil is shown below. Minoxidil is a K* channel opener and vasodilator used in the treatment of hair loss. NH2 POCI3 NH3 HN NH N [6] CI CI [7] CI NH2 (13) (14) [8] MCPBA NH2 H. NH2 NH2 [9] CI NH2 (15) Minoxidil The synthesis of compound (13) is achieved using three molar equivalents of phosphoryl chloride. This reaction [6] proceeds via a mechanism similar to that seen in the Vilsmeier reaction. Provide a complete mechanism for the substitutions of all three oxygens. What is the driving force for this reaction [6]? (a)

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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