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8. According to this direct linear plot, what is the a. Vmax b. Km c. Daily Dose required to achieve a Cpss of 20 800- 600- Vm ng/day)

8. According to this direct linear plot, what is the a. Vmax b. Km c. Daily Dose required to achieve a Cpss of 20 800- 600- Vm ng/day)

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**Question 8:** According to this direct linear plot, what is the a. Vmax b. Km c. Daily Dose required to achieve a Cpss of 20 mg/L **Description of the Graph:** The graph illustrates a direct linear plot used for determining pharmacokinetic parameters. - **Axes:** - The y-axis represents the Dose, Vm (mg/day), ranging from 0 to 800. - The x-axis represents -Cp(average) and Km (mg/L), ranging from -30 to 20. - **Lines:** - The plot contains three lines: a blue line, a green line, and a red line, each with a different slope. - **Parameters:** - **Vmax (Vm):** Indicated by a horizontal arrow pointing to approximately 400 mg/day on the y-axis. - **Km:** Indicated by a vertical arrow at around 10 mg/L on the x-axis. **Objective:** The graph is utilized to find: - The maximum rate of reaction (Vmax). - The Michaelis constant (Km). - The daily dose required to reach a steady-state concentration (Cpss) of 20 mg/L, which involves locating the point where the desired Cpss intersects with the appropriate line on the graph.
Transcribed Image Text:**Question 8:** According to this direct linear plot, what is the a. Vmax b. Km c. Daily Dose required to achieve a Cpss of 20 mg/L **Description of the Graph:** The graph illustrates a direct linear plot used for determining pharmacokinetic parameters. - **Axes:** - The y-axis represents the Dose, Vm (mg/day), ranging from 0 to 800. - The x-axis represents -Cp(average) and Km (mg/L), ranging from -30 to 20. - **Lines:** - The plot contains three lines: a blue line, a green line, and a red line, each with a different slope. - **Parameters:** - **Vmax (Vm):** Indicated by a horizontal arrow pointing to approximately 400 mg/day on the y-axis. - **Km:** Indicated by a vertical arrow at around 10 mg/L on the x-axis. **Objective:** The graph is utilized to find: - The maximum rate of reaction (Vmax). - The Michaelis constant (Km). - The daily dose required to reach a steady-state concentration (Cpss) of 20 mg/L, which involves locating the point where the desired Cpss intersects with the appropriate line on the graph.
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