8. A patiènt sullering from infectious polyarthritis, has been receiving prednišone for a long time as treatment. Prednisone is a structural analogue of cortisol. As the patient felt better, he deliberately stopped taking this drug. Soon the patient's state took a dramatical turn for the worse. Screening showed a deerease in the patient's blood glucose concentration, the blood pressure dropped, and the content of 17-ketosteroids in the urine was diminished. Why did the patient's state worsen after he quitted this drug? For the answer: a) draw a flowchart of hormone synthesis and secretion for the hormone with inhibited production caused by the prolonged administration of prednisone; b) predict an improvement in the patient's state if he is given corticotropin; c) name the reasons for the blood glucose concentration and 17-ketosteroids decrease and blood pressure decline; write the metabolic pathway with its decreased rate in the liver when prednisone administration was stopped; d) substantiate the prednisone use to treat arthritis.

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