7. Design a synthesis for the following reaction. Include all reagents and in the is 2correct order. You must use the acetoacetic ester synthesis reaction as part of 10 109100your synthesis.?CH₂+ Gi8a. How many 13C-NMR signals would the product of the reaction below have?b. Would the product have an M:M+2 peak? If yes, what is the ratio?israi Jed Wo1. HNO3, H2SO4IHO 2esoxs I2. Fe, HCI3. CH3COCI4. Br2, AlBr35. NaOH6. NaNO2, HCIH3PO2OH.OBA.SSHM

acetoacetic ester is a good source of nucleophile, thus in presence of base it generates enolate ion…

Answered: 7. Design a synthesis for the following…

7. Design a synthesis for the following reaction. Include all reagents and in the 2 correct order. You must use the acetoacetic ester synthesis reaction as part of your synthesis. ? CH₂

EBK A SMALL SCALE APPROACH TO ORGANIC L

4th Edition

ISBN:9781305446021

Author:Lampman

Publisher:Lampman

Chapter61: Friedel–crafts Acylation

Section: Chapter Questions

Problem 8Q

See similar textbooks

Related questions

Q: 1. Give the reau on mechanism(s) for the formation of the indicated products below. Be clear about…

A: Addition of HBr to alkene produces alkyl bromide. The addition of HBr (hydrogen bromide) to an…

Q: I'm a little confused on how to do the calculations. How do I do the calculations for this?…

Q: a. draw an arrow pointing at each of the amide bonds in the peptide below. b. All amide bonds are…

A: A carboxylic acid group (-COOH) and an amine group (-NH2) in condensed to form an amide bond (-CONH)…

Q: A student determines the value of the equilibrium constant to be 1.87 x 107 for the following…

Q: What is the pressure (in atm) of sample 1.000 moles of helium at 295.0k with volume of 25.00 L.

Q: Write a complete equation for the reaction of two methanol molecules with propanal.

A: The given question describes the reaction between aldehyde and two molecules of methanol to give…

Q: How does the body utilize amino acids which are not needed for the synthesis of proteins and other…

A: Amino acids which are not needed for protein synthesis are typically broken down by the body rather…

Q: 12.a. Consider AlCl3. What is the hybridization of Al in AlCl3? 12.b. Draw the electron…

A: Aluminum chloride (AlCl3) is an ionic compound that exists as a crystalline solid at room…

Q: 3. Identify the nucleophile that has added to acetone to give the following products: (a) OH (b) OH…

A: Acetone contains an electrophilic carbon centre. So nucleophile can easily attack the electrophilic…

Q: The energy of the absorption band in the electronic spectrum of the [Ti(H2O)6]3+ complex is 20300…

A: Stability of a complex can be explained by CFSE i.e. crystal field stabilisation energy. For this…

Q: Consider a reaction occurring in a battery. If ΔG° = -211 kJ/mol for the reaction and there are 4…

A: Given is: ΔG° = -211 kJ/mol n = 4 (electrons) E° = ?

Q: Calculate AH, rxn CH4 + Cl₂ ⇒ CH₂Cl + HCI NH3 + O₂ → H₂O + NO Bond HIM MIC HIN 410 610 C-C C-N 610…

A: When a bond is broken then energy is absorbed and when a bond is formed then energy is released. So…

Q: 4. Using the periodic table, arrange the following sets in order of increasing sizes; a. C, AI, O, K…

A: A question based on atoms. 2 sets of questions are given that are to be answered based on the size…

Q: 2. Show how the synthetic transformation shown below could be carried out. More than one step is…

Q: Draw a reasonable mechanism for this reaction. All compounds involved in each stage of the mechanism…

A: We have reaction of acetone with the base in aqueous medium. Acetone can undergo aldol type…

Q: elect ALL of the following that can be used to explain the polarities of NO2 and SeCl42- (these…

A: Here we have to choose the option which explain the polarities of NO2 and SeCl42- - Due to the…

Q: What is the equilibrium pH of a solution that is 0.00887 M in sulfuric acid? Sulfuric acid is the…

Q: 2-Methyl-2-propanol, (CH3)3COH, (12.7mL; d= 0.79 g/mL) was reacted with 30.0mL of concentrated…

A: Volume of (CH3)3COH = 12.7 mL volume of HCl = 30.0 mL density of (CH3)3COH = 0.79 g/mL molarity…

Q: [Co(ONO) 3 (NH3)3] : [Fe(ox)2(H₂O)2]: [Pt(py)4] [PtCl4] : [Ni(NH3)6](OH)2: K₂ [FeO4]:

Q: Which of the following processes is an oxidation? Fe³+ → Fe²+ NADH → NAD+ A. B. C. FAD D. E. FADH₂…

A: A question based on introduction to chemistry. 5 options are given that are to be distinguished on…

Q: 13. Using the data in Appendix C (attached), calculate AG using AG° = AG products - AG, to #5…

Q: Give detailed Solution

A: The relation between Gibbs free energy(∆G°), equilibrium constant(K) and temperature (T) is:…

Q: Check the box under each compound that exists as a pair of mirror-image twins. If none of them do,…

A: Answer: Compound that has chiral center can have mirror image twin that can't be superimposed on it…

Q: From the reaction 2 C12H22011 (g) + 24 O2 (g) -->24 CO2 (g) + 22 H₂O (1) Calculate the number of…

A: Since you have posted multiple questions, we will provide the solution only to the first question as…

Q: 3. Write an equation for hydration of trans-3-methyl-2-pentene. Label major and minor products and…

A: Organic reagents are chemical compounds that undergo functional group transformation.

Q: How much energy is required to raise the temperature of 14.7 grams of gaseous nitrogen from 22.4 °C…

A: To calculate the energy required to raise the temperature of a substance, we use the formula: Q = m…

Q: Draw open structures of these coordination compounds. Sodium tetracyanonicalate(II) ,…

Q: Consider the reaction: H,CO(g)+O,(g) → CO,(g)+H,O(1) Using standard thermodynamic data at 298 K,…

Q: Humans are heterotrophs that consume food for energy. These foods comprise of sugars that are broken…

A: Since you have asked a question with multiple subparts, we will solve the first three subparts for…

Q: The enthalpy of sublimation (atomization) of Re is 704 kJ mol–1. Explain why it is significantly…

A: The enthalpy of sublimation, also known as the enthalpy of atomization, is a thermodynamic quantity…

Q: What is the pH of 0.0125 M of NaHC2O4 pka1 1.250 pka2 4.266 How to determine 1st and 2nd…

Q: Predict the major organic product of the following reaction. 8.8 요 excess NaOEt EtOH ? =O

A: The proposed reaction scheme including reaction mechanism is shown below. The structure of the major…

Q: Write the cell notation for an electrochemical cell consisting of an anode where Cu (s) is oxidized…

A: Given

Q: Which of the following is true when comparing the ß-oxidation of a naturally occurring unsaturated…

Q: What is the molar mass of a gas that diffuses 3.16 times slower than fluorine gas? 1.90 g/mole 3.81…

A: Given, The rate of diffusion of unknown gas is 3.16 times slower than fluorine gas. Rate of…

Q: 5. Provide the product for the Michael addition reaction below and also propose a detailed…

A: The given reaction is shown below We have to predict the Michael addition product.

Q: Enter electrons as e The following skeletal oxidation-reduction reaction occurs under acidic…

A: Oxidation is increase in oxidation state or loss of electron.

Q: A reaction has a rate law of Rate = (1.25 M³²s¹)[A][B]². What concentration of [B] would give the…

Q: A gas cylinder contains 2.2 mol of N2, 3.3 mol of O2 and 4.4 mol of Cl2. What is the partial…

A: The partial pressure (Pa) of a gas 'a' in a mixture is given by: Pa=χa×PT Here PT is the total…

Q: Which SN2 reaction is faster? R-CH₂-OTS + Nu Nu: 1- or C6H5O- R-CH₂-Nu

A: The question is based on nucleophilic substitution reaction SN2. we need to identify the reaction…

Q: synthesis problem, start with 2 or fewer carbons and in the end, go back to 1-2 carbons #1 ✓ #2 C

A: The given compounds are shown below We have to synthesized the above two compounds using two or…

Q: For the reaction Use the References to access important values if needed for this question. Ca(OH)2…

A: Answer: Below shown formula will be used to calculate standard Gibbs free energy change:…

Q: Examine the geometry of the molecule in the window. ball & stick + labels The molecule has a…

A: In given Ball and Stick diagram, There are three different types of balls. Grey ball has 4 sticks…

Q: What is the pH of a solution that is 0.271 M in sodium formate (NaCHO₂)? The K₂ of formic acid is…

A: Ka of Formic acid = 1.8 x 10-4(NaCHO2) = 0.271M

Q: c) [Fe(bipy)3]²+ (i) (ii) (iii) (iv) Determine the oxidation state of the metal Give the…

Q: A mixture of He and Ne need to be separated. What will be the ratio of the rates of effusion of He…

A: According to Grahm's law of effusion, at similar temperature and pressure conditions rate of…

Q: Which of the products below would result from the indicated transamination reaction: A. I cooe +…

A: This reaction is dependent on coenzyme pyridoxyl phosphate that is PLP.

Q: The reaction A + B → 2 C has the rate law rate = k[A] [B]³. By what factor does the rate of reaction…

A: A + B → 2C The rate law is as follows: Rate1=k[A] [B]3 ...... (1)

Q: 5. Make the following via acetoacetic ester synthesis. Ţ Ji

Q: Which element meets all of the following conditions? is smaller than indium, In • has only one…

A: Ionization Energy: Ionization energy is the amount of energy required to remove an electron from a…

Concept explainers

Aldehydes and Ketones

Aldehydes and ketones are organic compounds that have a carbonyl group, C = O, as their functional group. They both differ in the placement of this carbonyl group in their structures.

Question

7. Design a synthesis for the following reaction. Include all reagents and in the is 2
correct order. You must use the acetoacetic ester synthesis reaction as part of 10 109100
your synthesis.
?
CH₂
+ Gi
8a. How many 13C-NMR signals would the product of the reaction below have?
b. Would the product have an M:M+2 peak? If yes, what is the ratio?israi Jed Wo
1. HNO3, H2SO4
IHO 2esoxs I
2. Fe, HCI
3. CH3COCI
4. Br2, AlBr3
5. NaOH
6. NaNO2, HCI
H3PO2
OH.OBA.S
SHM

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1: Theory

VIEW

Step 2: Answer

VIEW

Solution

VIEW

Step by step

Solved in 3 steps with 2 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

Can you detemine the substitution pattern on the aromatic ring from the following H NMR spectrum? Integrations for the signals are shown in blue. wlwwwulu 6.6 TTTE 8.6 8.4 8.2 8.0 7.8 7.6 7.4 7.2 7.0 6.8 ppm O A. Disubstituted: 1,3 O B. Trisubstituted: 1,2,4 O C. Disubstituted: 1,4 O D. Disubstituted: 1,2 O E. Monosubstituted 26 0 00 L
1. Provide the IUPAC name for: CO,H OH 2. Provide the structure of E-2,5-dimethyloct-5-enoic acid. 3. a. Name the structure with the following ¹H NMR spectrum. 8 (ppm) = 12.71 (1H, s), 8.04 (2H, d), 7.30 (2H, d), 2.41 (3H, s)
In the H NMR spectrum of the following substituted cyclobutane, the signal for H° would theoretically be split into how many peaks? CI на H. Br H. H. Br O 16 O 2 O 12 0 3 IDI %23 2 & 8 9 4 5 6 7 8. 9 Q W R T Y 4 5 A D F G (2 K C M alt
6 I have a NMR spectrum of my synthesized para nitroaniline sample, but it is dilluted. I try to figure out with what. I need a chemdraw from heptane, ethylacetate and ortho nitroaniline.
After the reduction of camphor with NaBH4 experiment, you took a 1H-NMR of your product sample. The sample ave the following 1H-NMR singlas with the given integrations (2.314 and 9.497). Determine the product ratio of isoboreneol to borneol in this particular mixture.
Match the spectra to the structures: 3-bromotoluene and methyl 4-methoxybenzoate. CH 3 3-bromotoluene 200 Spectrum B 200 Br (ignore the CDCI3 signal) CH3O methyl 4-methoxybenzoate OCH3 Spectrum A 100 100
2. Provide the structure of E-2,5-dimethyloct-5-enoic acid. 3. a. Name the structure with the following 'H NMR spectrum. 8 (ppm) = 12.71 (1H, s), 8.04 (2H, d), 7.30 (2H, d), 2.41 (3H, s)
You run the following reaction. Upon completion and isolation of the product you take the following carbon NMR. Which of the following products did you make? A) ОН О B) H. ole C) ОН D) I II 128 200 150 100 50 б (ppm)
How many ¹H NMR signals are present in the product of the reaction shown below? O O 00 9 1) CH3MgCI 2) H₂O
The following ¹H NMR spectrum is shown in two questions. "nmrsim presentation 1 1 C:\Bruker TopSpin3.5p17\examdata 10 The most de-shielded resonance can BEST be assigned to the following functional group: Methoxy group Methyl ester Methyl bromide (CH3Br) Aromatic ring [ppm] Aldehyde Deal
t: How does deuteroacetone-do show up on the carbon NMR spectrum? a quartet at 30 ppm and a singlet at 206 ppm O a singlet at 30 ppm and 206 ppm a triplet at 30 ppm O a singlet at 30 ppm Oa septet at 30 ppm and a singlet at 206 ppm
7. Which structure is consistent with this ¹H NMR spectrum? a) b) H CH₂CH3 O c) CH3CH₂. O OCH3 O CH₂CH3 d) H₂C, OCH₂CH3 PPM