54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin ea drug (Dramamine) is to be designed along me following lines. The drug is dissolved in a hin gelatin film and applied as a "patch" to the kin, much like a Band-Aid (see Fig. P4.54). The polymeric membranes that offer no resistance to passage of the drug. The drug is not volatile in the surrounding air. The diffusivity of Dra- mamine in the gelatin is 3 x 10-7 cim²/s. Find the gelatin film thickness such that 90% of the Dramamine is delivered to the skin over a 3- hour period. Assume that the skin region is so highly vascularized that the Dramamine concen- tration is practically zero in the skin and tissue beneath the patch. Film Skin Figure P4.54
54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin ea drug (Dramamine) is to be designed along me following lines. The drug is dissolved in a hin gelatin film and applied as a "patch" to the kin, much like a Band-Aid (see Fig. P4.54). The polymeric membranes that offer no resistance to passage of the drug. The drug is not volatile in the surrounding air. The diffusivity of Dra- mamine in the gelatin is 3 x 10-7 cim²/s. Find the gelatin film thickness such that 90% of the Dramamine is delivered to the skin over a 3- hour period. Assume that the skin region is so highly vascularized that the Dramamine concen- tration is practically zero in the skin and tissue beneath the patch. Film Skin Figure P4.54
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
Related questions
Question
![4.54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin
sea drug (Dramamine) is to be designed along
the following lines. The drug is dissolved in a
thin gelatin film and applied as a "patch" to the
skin, much like a Band-Aid (see Fig. P4.54). The
polymeric membranes that offer no resistance
to passage of the drug. The drug is not volatile
in the surrounding air. The diffusivity of Dra-
mamine in the gelatin is 3 x 107 cm²/s. Find
the gelatin film thickness such that 90% of the
Dramamine is delivered to the skin over a 3-
hour period. Assume that the skin region is so
highly vascularized that the Dramamine concen-
tration is practically zero in the skin and tissue
beneath the patch.
Film
Skin
Figure P4.54](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcb1cc6be-d758-43b5-95ea-09c15572ab6a%2F6d10dc01-508f-4068-8eb7-9b8f62caf452%2Fxp4rqdm_processed.png&w=3840&q=75)
Transcribed Image Text:4.54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin
sea drug (Dramamine) is to be designed along
the following lines. The drug is dissolved in a
thin gelatin film and applied as a "patch" to the
skin, much like a Band-Aid (see Fig. P4.54). The
polymeric membranes that offer no resistance
to passage of the drug. The drug is not volatile
in the surrounding air. The diffusivity of Dra-
mamine in the gelatin is 3 x 107 cm²/s. Find
the gelatin film thickness such that 90% of the
Dramamine is delivered to the skin over a 3-
hour period. Assume that the skin region is so
highly vascularized that the Dramamine concen-
tration is practically zero in the skin and tissue
beneath the patch.
Film
Skin
Figure P4.54
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