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- 1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…1. What is pharmaceutical dosage? 2. What is the contribution of pharmaceutical dosage to the field of pharmacy?1. Explain the importance of solubility in drug product formulation. 2.
- 5. What is a hospital formulary? What is its importance in the hospital pharmacy setting?7. For those drugs that need to be applied with dissolution sustained system, what are their original properties? A. Low aqueous solubility and slow dissolution rate B. High aqueous solubility and slow dissolution rate C. Low aqueous solubility and fast dissolution rate D. High aqueous solubility and fast dissolution rate E. Gaseous state in room temperature with low aqueous solubility 8. Which of the following drug injection methods does involve perpendicularly inserting needle to the patient's body? A. Intramuscular injection B. Intravenous injection C. Subcutaneous injection D. Intradermal injection E. None of the above 9. Which of the following proteins is NOT commonly bound with drug in the bloodstream? A. Albumins B. Globulins C. Fibrinogens D. Antibodies E. None of the above 10. Which of the following events cannot increase the bioavailability of a drug? A. Patients suffer from cirrhosis B. Patients suffer from diarrhea C. Switch to intravenous injection from oral administration…1. Calamine Lotion is classified as a suspension. What is a suspension? A. It is a disperse system in which solid, vehicle-insoluble particles (internal phase) are uniformlysuspended by mechanical agitation and formulation design throughout the liquid vehicle(external phase).B. It is a clear, flavored, sweetened, hydroalcoholic liquid oral preparation that usually containeither potent or unpleasant tasting drugsC. It is a concentrated aqueous solution containing one or more sugar components, chiefly sucrose,or sugar substituteD. It is a viscous oral liquid containing one or more medicament dissolved in a vehicle that usuallycontains high proportion of sucrose or other sugars.
- Discuss the effects of glass packaging materials on pharmaceutical dosage form? Discuss at your own words5. Order: Penicillin V potassium 1 tsp q.i.d. x 10 days Available: 10-g bottle of penicillin V potassium oral suspension with the following instructions: Add 117 mL water to yield 200 mL oral solution. Each teaspoon will contain how much? mg21. If the adult dose for a drug is 500 mg, what is the dose (in milligrams) for a child who has a BSA of 0.43 m2? Round to the nearest whole milligram.
- 5 write 2 pages on illicit drug composition and analytical techniques.3. Based on the name of the following hypothetical drug salts, which of the following statements is correct for the parent drugs (in their unionized forms)? A. Catodium potassium B. Dogodium tartarate C. Hungaryon acetate D. Cureitall hydrobromide E. Eddyolone triethyamine A) A and E are acidic B) B and C are acidic C) A and E are basic D) C and D are basic E) D and E are acidic1. Choose a specific drug name (NOT A DRUG CLASS) under CELL WALL SYNTHESIS INHIBITORS, and DRAW the structure. 2. Write the Name of the drug, the drug classification, and the brief mechanism of action. 3. Label/Encircle the the functional group/s with their corresponding SAR. Briefly explain.