5. Sickle cell disease is inherited in an autosomal recessive manner. If Josh and Katie each have a sibling with sickle cell disease, but neither Josh nor Katie nor any of their parents have the disease, then what is the chance that a child of Josh and Katie's will have sickle cell disease? (Hint: First determine the chance that Josh and Katie are carriers of the disease.)

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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5. Sickle cell disease is inherited in an autosomal recessive manner. If Josh and Katie each have a sibling
with sickle cell disease, but neither Josh nor Katie nor any of their parents have the disease, then what is
the chance that a child of Josh and Katie's will have sickle cell disease? (Hint: First determine the chance
that Josh and Katie are carriers of the disease.)
Transcribed Image Text:5. Sickle cell disease is inherited in an autosomal recessive manner. If Josh and Katie each have a sibling with sickle cell disease, but neither Josh nor Katie nor any of their parents have the disease, then what is the chance that a child of Josh and Katie's will have sickle cell disease? (Hint: First determine the chance that Josh and Katie are carriers of the disease.)
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Introduction :- 

Sickle cell anemia is a genetic blood disorder that affects the shape and function of red blood cells. It is caused by a mutation in the HBB gene, which provides instructions for making a protein called beta-globin. This mutation causes the red blood cells to become stiff, sticky, and sickle-shaped, rather than the normal round shape

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