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### Understanding Sickle-Cell Inheritance Sickle-cell disease is an autosomal recessive disorder. This means it occurs when an individual inherits two copies of the mutated gene, one from each parent. #### Problem Statement A father with sickle-cell disease is told that the disease will "skip a generation" since none of his children will have the disorder, but his grandchildren could inherit it since his children will all be carriers. What is the mother's genotype? #### Options for Mother's Genotype: 1. ◯ Normal 2. ◯ Carrier 3. ◯ Diseased 4. ◯ SS 5. ◯ Ss 6. ◯ ss To understand this better, we need to know about the genotypes associated with sickle-cell disease: - **SS**: Normal (no disease, not a carrier) - **Ss**: Carrier (no disease, but can pass the mutated gene to offspring). - **ss**: Diseased (has sickle-cell disease). Given that the father has sickle-cell disease (ss), and knowing that the disease is recessive, we need to find out what the mother’s genotype must be for none of their children to have the disease, while enabling the disease to skip a generation. #### Explanation Since sickle-cell disease is autosomal recessive: - If the father is **ss** and the mother is **SS**, their children would all be **sS** (carriers but not diseased). - If the mother is **Ss**, the children may either be carriers (Ss) or diseased (ss). Given the information that none of the children will have the disease, the only possible genotype for the mother is **SS** or **Ss**. However, for the disease to skip a generation, she must be a carrier **Ss**. Thus, the answer is: 5. ◯ Ss ### Conclusion On an educational website, this problem and solution help illustrate the principles of autosomal recessive inheritance, particularly in the context of genetic disorders such as sickle-cell disease. Understanding how carriers work and how recessive genes are passed down is crucial in genetics and helps in understanding inheritance patterns.

### Understanding Sickle-Cell Inheritance Sickle-cell disease is an autosomal recessive disorder. This means it occurs when an individual inherits two copies of the mutated gene, one from each parent. #### Problem Statement A father with sickle-cell disease is told that the disease will "skip a generation" since none of his children will have the disorder, but his grandchildren could inherit it since his children will all be carriers. What is the mother's genotype? #### Options for Mother's Genotype: 1. ◯ Normal 2. ◯ Carrier 3. ◯ Diseased 4. ◯ SS 5. ◯ Ss 6. ◯ ss To understand this better, we need to know about the genotypes associated with sickle-cell disease: - **SS**: Normal (no disease, not a carrier) - **Ss**: Carrier (no disease, but can pass the mutated gene to offspring). - **ss**: Diseased (has sickle-cell disease). Given that the father has sickle-cell disease (ss), and knowing that the disease is recessive, we need to find out what the mother’s genotype must be for none of their children to have the disease, while enabling the disease to skip a generation. #### Explanation Since sickle-cell disease is autosomal recessive: - If the father is **ss** and the mother is **SS**, their children would all be **sS** (carriers but not diseased). - If the mother is **Ss**, the children may either be carriers (Ss) or diseased (ss). Given the information that none of the children will have the disease, the only possible genotype for the mother is **SS** or **Ss**. However, for the disease to skip a generation, she must be a carrier **Ss**. Thus, the answer is: 5. ◯ Ss ### Conclusion On an educational website, this problem and solution help illustrate the principles of autosomal recessive inheritance, particularly in the context of genetic disorders such as sickle-cell disease. Understanding how carriers work and how recessive genes are passed down is crucial in genetics and helps in understanding inheritance patterns.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Understanding Sickle-Cell Inheritance Sickle-cell disease is an autosomal recessive disorder. This means it occurs when an individual inherits two copies of the mutated gene, one from each parent. #### Problem Statement A father with sickle-cell disease is told that the disease will "skip a generation" since none of his children will have the disorder, but his grandchildren could inherit it since his children will all be carriers. What is the mother's genotype? #### Options for Mother's Genotype: 1. ◯ Normal 2. ◯ Carrier 3. ◯ Diseased 4. ◯ SS 5. ◯ Ss 6. ◯ ss To understand this better, we need to know about the genotypes associated with sickle-cell disease: - **SS**: Normal (no disease, not a carrier) - **Ss**: Carrier (no disease, but can pass the mutated gene to offspring). - **ss**: Diseased (has sickle-cell disease). Given that the father has sickle-cell disease (ss), and knowing that the disease is recessive, we need to find out what the mother’s genotype must be for none of their children to have the disease, while enabling the disease to skip a generation. #### Explanation Since sickle-cell disease is autosomal recessive: - If the father is **ss** and the mother is **SS**, their children would all be **sS** (carriers but not diseased). - If the mother is **Ss**, the children may either be carriers (Ss) or diseased (ss). Given the information that none of the children will have the disease, the only possible genotype for the mother is **SS** or **Ss**. However, for the disease to skip a generation, she must be a carrier **Ss**. Thus, the answer is: 5. ◯ Ss ### Conclusion On an educational website, this problem and solution help illustrate the principles of autosomal recessive inheritance, particularly in the context of genetic disorders such as sickle-cell disease. Understanding how carriers work and how recessive genes are passed down is crucial in genetics and helps in understanding inheritance patterns.
Transcribed Image Text:### Understanding Sickle-Cell Inheritance Sickle-cell disease is an autosomal recessive disorder. This means it occurs when an individual inherits two copies of the mutated gene, one from each parent. #### Problem Statement A father with sickle-cell disease is told that the disease will "skip a generation" since none of his children will have the disorder, but his grandchildren could inherit it since his children will all be carriers. What is the mother's genotype? #### Options for Mother's Genotype: 1. ◯ Normal 2. ◯ Carrier 3. ◯ Diseased 4. ◯ SS 5. ◯ Ss 6. ◯ ss To understand this better, we need to know about the genotypes associated with sickle-cell disease: - **SS**: Normal (no disease, not a carrier) - **Ss**: Carrier (no disease, but can pass the mutated gene to offspring). - **ss**: Diseased (has sickle-cell disease). Given that the father has sickle-cell disease (ss), and knowing that the disease is recessive, we need to find out what the mother’s genotype must be for none of their children to have the disease, while enabling the disease to skip a generation. #### Explanation Since sickle-cell disease is autosomal recessive: - If the father is **ss** and the mother is **SS**, their children would all be **sS** (carriers but not diseased). - If the mother is **Ss**, the children may either be carriers (Ss) or diseased (ss). Given the information that none of the children will have the disease, the only possible genotype for the mother is **SS** or **Ss**. However, for the disease to skip a generation, she must be a carrier **Ss**. Thus, the answer is: 5. ◯ Ss ### Conclusion On an educational website, this problem and solution help illustrate the principles of autosomal recessive inheritance, particularly in the context of genetic disorders such as sickle-cell disease. Understanding how carriers work and how recessive genes are passed down is crucial in genetics and helps in understanding inheritance patterns.
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