5. Indicate which one of the following statements is not correct: a. Drugs that are taken up into the body through the gastrointestinal mucosa will be transported to the liver via the portal vein before going into general circulation. b. If the drug is susceptible to metabolic degradation in the liver, this may considerably enhance the activity of the drug. This phenomenon is known as the hepatic first-pass effect. c. Therectal route may also show varying degrees of the first-pass effect. d. In other routes of administration (intravenous, vaginal, nasal, buccal and sublingual) the drug is distributed in the body before reaching the liver. Whilst the liver is the main metabolic organ of the body, metabolism may also take place in the gastrointestinal lumen and indeed in the е. mucosal membranes.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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5. Indicate which one of the following statements is not correct:
a. Drugs that are taken up into the body through the gastrointestinal
mucosa will be transported to the liver via the portal vein before going
into general circulation.
b. If the drug is susceptible to metabolic degradation in the liver, this
may considerably enhance the activity of the drug. This phenomenon
is known as the hepatic first-pass effect.
c. Therectal route may also show varying degrees of the first-pass effect.
d. In other routes of administration (intravenous, vaginal, nasal, buccal
and sublingual) the drug is distributed in the body before reaching the
liver.
Whilst the liver is the main metabolic organ of the body, metabolism
may also take place in the gastrointestinal lumen and indeed in the
е.
mucosal membranes.
Transcribed Image Text:5. Indicate which one of the following statements is not correct: a. Drugs that are taken up into the body through the gastrointestinal mucosa will be transported to the liver via the portal vein before going into general circulation. b. If the drug is susceptible to metabolic degradation in the liver, this may considerably enhance the activity of the drug. This phenomenon is known as the hepatic first-pass effect. c. Therectal route may also show varying degrees of the first-pass effect. d. In other routes of administration (intravenous, vaginal, nasal, buccal and sublingual) the drug is distributed in the body before reaching the liver. Whilst the liver is the main metabolic organ of the body, metabolism may also take place in the gastrointestinal lumen and indeed in the е. mucosal membranes.
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