5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the reaction.

5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the reaction.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter26: Aldol And Claisen Reactions

Section: Chapter Questions

Problem 3CTQ

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5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the
carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the
reaction.

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