5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the reaction.
5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the reaction.
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter26: Aldol And Claisen Reactions
Section: Chapter Questions
Problem 3CTQ
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![5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the
carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the
reaction.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe651a1e9-6431-4411-84da-0b8f9688dde1%2F898252c1-6929-4fb3-9f21-21e21a5902c9%2Fptm1enc_processed.png&w=3840&q=75)
Transcribed Image Text:5. In the transition state for the proline-catalyzed aldol addition, a hydrogen bond is shown between the
carboxylic acid of proline and isobutyraldehyde. Explain how this could lower the energy barrier for the
reaction.
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