5) Show how you would use Friedel-Crafts acylation to prepare the following compound: Ph-C-CH,CH(CH,), isobutyl phenyl ketone

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**5) Show how you would use Friedel-Crafts acylation to prepare the following compound:**

The compound shown is isobutyl phenyl ketone, which has the structure:

     Ph–C(O)–CH₂CH(CH₃)₂

- Ph represents a phenyl group (C₆H₅).
- The acyl group is attached to a paraffinic chain designated as isobutyl.

To synthesize this compound using Friedel-Crafts acylation:

1. **Acyl Chloride Preparation**: 
   - Use isobutyryl chloride (CH₃CH(CH₃)C(O)Cl) as the acyl chloride reagent.

2. **Catalyst**:
   - Use a Lewis acid catalyst, such as aluminum chloride (AlCl₃), to activate the acyl chloride.

3. **Reaction with Benzene**:
   - React the acyl chloride with benzene in presence of AlCl₃ to introduce the acyl group onto the benzene ring, forming the desired ketone.

4. **Product**:
   - This will yield isobutyl phenyl ketone as the final product.

This reaction is a classic example of Friedel-Crafts acylation, which is often used to attach acyl groups to aromatic rings, forming aryl ketones.
Transcribed Image Text:**5) Show how you would use Friedel-Crafts acylation to prepare the following compound:** The compound shown is isobutyl phenyl ketone, which has the structure: Ph–C(O)–CH₂CH(CH₃)₂ - Ph represents a phenyl group (C₆H₅). - The acyl group is attached to a paraffinic chain designated as isobutyl. To synthesize this compound using Friedel-Crafts acylation: 1. **Acyl Chloride Preparation**: - Use isobutyryl chloride (CH₃CH(CH₃)C(O)Cl) as the acyl chloride reagent. 2. **Catalyst**: - Use a Lewis acid catalyst, such as aluminum chloride (AlCl₃), to activate the acyl chloride. 3. **Reaction with Benzene**: - React the acyl chloride with benzene in presence of AlCl₃ to introduce the acyl group onto the benzene ring, forming the desired ketone. 4. **Product**: - This will yield isobutyl phenyl ketone as the final product. This reaction is a classic example of Friedel-Crafts acylation, which is often used to attach acyl groups to aromatic rings, forming aryl ketones.
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