5' сТА АG-OC T G ATT сGA 3' 1 3' DNA contains oxidized guanine (G-O) as a result of oxidation damage. 5' 5' ČÍÁ Á G ATT сGA 3' 3 Glycosylase removes the oxidized nucleobase from the 5' sugar-phosphate backbone. 2 ст Cut 5' сТА А ст G ATT сGA 3' 3' At the site of the missing nucleobase, an enzyme cuts the 5' sugar-phosphate backbone. 5' 3' DNA polymerase degrades a short stretch of the strand. 5' ст G ATT сGA 3' 5' 3' The combined actions of DNA сТА А Gст G ATT сGA 3' polymerase and DNA ligase 1 5' fill in and seal the gap. FIGURE 8.11 Repair of Oxidized Guanine in

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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What would be the effect on cells if they did not have the glycosylase enzyme?

5'
сТА АG-OC T
G ATT сGA
3'
1
3'
DNA contains oxidized
guanine (G-O) as a result
of oxidation damage.
5'
5'
ČÍÁ Á
G ATT сGA
3'
3 Glycosylase removes the
oxidized nucleobase from the
5' sugar-phosphate backbone.
2
ст
Cut
5'
сТА А ст
G ATT сGA
3'
3'
At the site of the missing
nucleobase, an enzyme cuts the
5' sugar-phosphate backbone.
5'
3'
DNA polymerase degrades a
short stretch of the strand.
5'
ст
G ATT сGA
3'
5'
3'
The combined actions of DNA
сТА А Gст
G ATT сGA
3'
polymerase and DNA ligase
1 5' fill in and seal the gap.
FIGURE 8.11 Repair of Oxidized Guanine
in
Transcribed Image Text:5' сТА АG-OC T G ATT сGA 3' 1 3' DNA contains oxidized guanine (G-O) as a result of oxidation damage. 5' 5' ČÍÁ Á G ATT сGA 3' 3 Glycosylase removes the oxidized nucleobase from the 5' sugar-phosphate backbone. 2 ст Cut 5' сТА А ст G ATT сGA 3' 3' At the site of the missing nucleobase, an enzyme cuts the 5' sugar-phosphate backbone. 5' 3' DNA polymerase degrades a short stretch of the strand. 5' ст G ATT сGA 3' 5' 3' The combined actions of DNA сТА А Gст G ATT сGA 3' polymerase and DNA ligase 1 5' fill in and seal the gap. FIGURE 8.11 Repair of Oxidized Guanine in
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