40. A 42-year-old man is brought to the emergency department by his wife because of a 24-hour history of severe abdominal pain. His wife says that he has been drinking excessive amounts of alcohol for the past 3 days. His blood alcohol concentration is 160 mg/dL. Physical examination shows scleral icterus and right upper quadrant tenderness of the abdomen. Microscopic examination of a liver biopsy specimen shows hepatocyte necrosis, bridging portal fibrosis, and macrovesicular steatosis. There are numerous Mallory bodies and neutrophilic infiltrates. Which of the following abnormalities is most likely in this patient?

Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
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140. A 42-year-old man is brought to the emergency department by his wife because of a 24-hour history of severe abdominal pain. His wife says that he has been drinking excessive amounts of
alcohol for the past 3 days. His blood alcohol concentration is 160 mg/dL. Physical examination shows scleral icterus and right upper quadrant tenderness of the abdomen. Microscopic
examination of a liver biopsy specimen shows hepatocyte necrosis, bridging portal fibrosis, and macrovesicular steatosis. There are numerous Mallory bodies and neutrophilic infiltrates.
Which of the following abnormalities is most likely in this patient?
A) Globules of a-antitrypsin
OB) Impaired synthesis of fatty acids
C) Increased conjugation of bilirubin
D) Increased generation of ATP by mitochondria
E) Increased NADH/NAD* ratio
F) Increased oxidation of fatty acids
Transcribed Image Text:140. A 42-year-old man is brought to the emergency department by his wife because of a 24-hour history of severe abdominal pain. His wife says that he has been drinking excessive amounts of alcohol for the past 3 days. His blood alcohol concentration is 160 mg/dL. Physical examination shows scleral icterus and right upper quadrant tenderness of the abdomen. Microscopic examination of a liver biopsy specimen shows hepatocyte necrosis, bridging portal fibrosis, and macrovesicular steatosis. There are numerous Mallory bodies and neutrophilic infiltrates. Which of the following abnormalities is most likely in this patient? A) Globules of a-antitrypsin OB) Impaired synthesis of fatty acids C) Increased conjugation of bilirubin D) Increased generation of ATP by mitochondria E) Increased NADH/NAD* ratio F) Increased oxidation of fatty acids
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