4.48 The weak base colloquially known as Tris, and more precisely as tris(hydroxymethyl)aminomethane, has pKa =8.3 at 20°C and is commonly used to produce a buffer for biochemical applications. (a) At what pH would you expect Tris to act as a buffer in a solution that has equal molar concentrations of Tris and its conjugate acid? (b) What is the pH after the addition of 3.3 mmol NaOH to 100 cm3 of a buffer solution with equal molar concentrations of Tris and its conjugate acid form? (c) What is the pH after the addition of 6.0 mmol HNO3 to 100 cm3 of a buffer solution with equal molar concentrations of Tris and its conjugate acid?

4.48 The weak base colloquially known as Tris, and more precisely as tris(hydroxymethyl)aminomethane, has pKa =8.3 at 20°C and is commonly used to produce a buffer for biochemical applications. (a) At what pH would you expect Tris to act as a buffer in a solution that has equal molar concentrations of Tris and its conjugate acid? (b) What is the pH after the addition of 3.3 mmol NaOH to 100 cm3 of a buffer solution with equal molar concentrations of Tris and its conjugate acid form? (c) What is the pH after the addition of 6.0 mmol HNO3 to 100 cm3 of a buffer solution with equal molar concentrations of Tris and its conjugate acid?

Chemistry

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Chapter1: Chemical Foundations

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Bronsted-Lowry base in inorganic chemistry is any chemical substance that can accept a proton from the other chemical substance it is reacting with.

Question

4.48 The weak base colloquially known as Tris, and more precisely as tris(hydroxymethyl)aminomethane,
has pKa = 8.3 at 20°C and is commonly used to produce a buffer for biochemical applications. (a) At
what pH would you expect Tris to act as a buffer in a solution that has equal molar concentrations of Tris
and its conjugate acid? (b) What is the pH after the addition of 3.3 mmol NaOH to 100 cm3 of a buffer
solution with equal molar concentrations of Tris and its conjugate acid form? (c) What is the pH after the
addition of 6.0 mmol HNO3 to 100 cm3 of a buffer solution with equal molar concentrations of Tris and its
conjugate acid?

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